Reactogenicity to COVID-19 vaccination in the United States of America

Sanyaolu, Adekunle; Marinkovic, Aleksandra; Prakash, Stephanie; Desai, Priyank; Haider, Nafees; Abbasi, Abdus Sattar; Mehraban, Nasima; Jain, Isha; Ekeh, Amarachi; Shazley, Omar; Okorie, Chuku; Orish, Verner N.

doi:10.7774/cevr.2022.11.1.104

Cited by 7 publications

(4 citation statements)

References 22 publications

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“…However, we reported an increase in the frequency of AEs after the Sputnik V vaccine, local AEs after the Sinopharm vaccine, systemic AEs after the Pfizer-BioNTech vaccine, and serious AEs after the Johnson & Johnson (J&J) vaccine. Previous studies have shown different trends, with higher local and systemic AEs reported after the second dose of Pfizer-BioNTech and AstraZeneca vaccines 26 , 50 – 52 .…”

Section: Discussionmentioning

confidence: 89%

Exploring the reported adverse effects of COVID-19 vaccines among vaccinated Arab populations: a multi-national survey study

Amer,

Al-Zahrani,

Imam

et al. 2024

Sci Rep

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The coronavirus disease 2019 (COVID-19) pandemic has been a major challenge worldwide for the past years with high morbidity and mortality rates. While vaccination was the cornerstone to control the pandemic and disease spread, concerns regarding safety and adverse events (AEs) have been raised lately. A cross-sectional study was conducted between January 1st and January 22nd, 2022, in six Arabic countries namely Saudi Arabia, Egypt, Syria, Libya, Iraq, and Algeria. We utilized a self-administered questionnaire validated in Arabic which encompassed two main parts. The first was regarding sociodemographic data while the second was about COVID-19 vaccination history, types, doses, and experienced AEs. A multistage sampling was employed in each country, involving the random selection of three governorates from each country, followed by the selection of one urban area and one rural area from each governorate. We included the responses of 1564 participants. The most common AEs after the first and second doses were local AEs (67.9% and 46.6%, respectively) followed by bone pain and myalgia (37.6% and 31.8%, respectively). After the third dose, the most common AEs were local AEs (45.7%) and fever (32.4%). Johnson and Johnson, Sputnik Light, and Moderna vaccines showed the highest frequency of AEs. Factors associated with AEs after the first dose included an increase in age (aOR of 61–75 years compared to the 12–18 years group: 2.60, 95% CI: 1.59–4.25, p = 0.001) and male gender (OR: 0.72, 95% CI: 0.63–0.82, p < 0.001). The cumulative post-vaccination COVID-19 disease was reported with Sinovac (16.1%), Sinopharm (15.8%), and Johnson and Johnson (14.9) vaccines. History of pre-vaccination SARS-CoV-2 infection significantly increases the risk of post-vaccination COVID-19 after the first, second, and booster doses (OR: 3.09, CI: 1.9–5.07, p < 0.0001; OR: 2.56, CI: 1.89–3.47, p < 0.0001; and OR: 2.94, CI: 1.6–5.39, p = 0.0005 respectively). In conclusion, AEs were common among our participants, especially local AEs. Further extensive studies are needed to generate more generalizable data regarding the safety of different vaccines.

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Section: Discussionmentioning

confidence: 89%

Exploring the reported adverse effects of COVID-19 vaccines among vaccinated Arab populations: a multi-national survey study

Amer,

Al-Zahrani,

Imam

et al. 2024

Sci Rep

View full text Add to dashboard Cite

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“…Women often have greater humoral and cell-mediated immune responses than men after antigenic stimulation, including vaccination and infection [ 45 ]. Similarly, women have a more pronounced immune response than men after seasonal influenza vaccination [ 46 ]. This finding may be due to the greater absolute number of CD4-positive (CD41) lymphocytes in women than in men [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Protective Anti-HBs Antibodies and Response to a Booster Dose in Medical Students Vaccinated at Childhood

Coppeta,

Ferrari,

Verno

et al. 2023

Vaccines

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The immune system in humans is regulated by the circadian rhythm. Published studies have reported that the time of vaccination is associated with the immune response to vaccine for some pathogens. Our study aimed to evaluate the association between time of dose administration of challenge HBV vaccine and seroconversion for anti-HBs in medical students vaccinated at birth who were found to be unprotected at pre-training screening. Humoral protection for HBV was assessed in 885 medical students vaccinated during childhood. In total, 359 (41.0%) of them showed anti-HBs titer < 10 UI/mL and received a challenge dose of HBV vaccine followed by post-vaccination screening 30–60 days later. The challenge dose elicited a protective immune response (anti-HBs IgG titer > 10 UI/mL) in 295 (83.8%) individuals. Seroconversion was significantly associated with female gender and time of vaccination after controlling for age group and nationality at logistic regression analysis. Students who received the booster dose in the morning had a higher response rate than those who received the vaccine in the afternoon (OR 1.93; 95% C.I. 1.047–3.56: p < 0.05). This finding suggests that morning administration of the HBV booster may result in a better immune response in susceptible individuals.

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“…Accordingly, women show a more pronounced immune response than men after being vaccinated with seasonal influenza [27]. This finding may be due to the greater number of absolute of CD4-positive (CD41) lymphocytes in women than men [28]. Similarly, women have greater production of TH1 cytokines [29,30], thereby resulting in higher postvaccination release of neutralizing antibodies.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Adverse Effects after the Second Dose of BNT162b2 Mrna Vaccination for COVID-19: A Survey-based Analysis among Italian Healthcare Workers

Ferrazza,

Nucera,

Longo

et al. 2023

TOPHJ

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Backgrounds and Aims: Since the start of the SARS-CoV-2 pandemic, healthcare workers have been at elevated risk of contracting COVID-19. Although COVID-19 vaccines have contributed to the eradication of, or substantial decreases in, the incidence of lethal diseases, the major determinant of COVID-19 vaccine hesitancy is a fear of associated adverse effects. Here, we performed a survey assessing the reactogenicity and safety of BNT162b2 in a real-world setting. Methods: Data were collected from March 1 and June 14, 2021. A total of 206 hospital employees undergoing BNT162b2 mRNA vaccination completed the survey. These hospital workers received a questionnaire to collect the common and uncommon adverse effects developing 2–6 days after the second dose of the Pfizer-BioNTech vaccine. Results: After the second dose, female sex was found to be associated with a higher risk of vaccine-related severe systemic adverse effects than male sex (odds ratio [OR] 3.116, 95% CI 2.365–7.113). We also observed that the anti-SARS-CoV-2 receptor-binding domain titer, determined on the day when the second dose of the Pfizer-BioNTech vaccine was administered, was significantly higher in participants with severe systemic effects than those without such effects (OR 1.017, 95% CI 1.001–1.034). Conclusion: Our study suggested that healthy female healthcare workers had a three-fold higher risk than healthy male healthcare workers of developing severe adverse effects after the second dose of the Pfizer-BioNTech vaccine. Further research is warranted to determine whether a high anti-SARS-CoV-2 RBD titer determined at the time of the second vaccination might indicate a disproportionate inflammatory systemic reaction leading to severe adverse effects. Our findings might contribute to a decrease in the disappearance of COVID-19 vaccine hesitancy.

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Reactogenicity to COVID-19 vaccination in the United States of America

Cited by 7 publications

References 22 publications

Exploring the reported adverse effects of COVID-19 vaccines among vaccinated Arab populations: a multi-national survey study

Exploring the reported adverse effects of COVID-19 vaccines among vaccinated Arab populations: a multi-national survey study

Protective Anti-HBs Antibodies and Response to a Booster Dose in Medical Students Vaccinated at Childhood

Evaluation of Adverse Effects after the Second Dose of BNT162b2 Mrna Vaccination for COVID-19: A Survey-based Analysis among Italian Healthcare Workers

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