Reactor-Produced Therapeutic Radionuclides

Knapp, F. F.; Dash, Ashutosh

doi:10.1007/978-81-322-2607-9_5

Cited by 3 publications

(1 citation statement)

References 242 publications

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“…The 177m Lu/ 177 Lu generator could complement the present 177 Lu production routes. In the current situation, two different production routes are established: the indirect and direct routes 11 12 26 . In the indirect route, 177 Lu is produced as the decay product of the short-lived 177 Yb, which is produced by neutron capture of enriched 176 Yb 27 .…”

Section: Discussionmentioning

confidence: 99%

Separation of nuclear isomers for cancer therapeutic radionuclides based on nuclear decay after-effects

Bhardwaj

Meer

Das

et al. 2017

Sci Rep

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177Lu has sprung as a promising radionuclide for targeted therapy. The low soft tissue penetration of its β− emission results in very efficient energy deposition in small-size tumours. Because of this, 177Lu is used in the treatment of neuroendocrine tumours and is also clinically approved for prostate cancer therapy. In this work, we report a separation method that achieves the challenging separation of the physically and chemically identical nuclear isomers, 177mLu and 177Lu. The separation method combines the nuclear after-effects of the nuclear decay, the use of a very stable chemical complex and a chromatographic separation. Based on this separation concept, a new type of radionuclide generator has been devised, in which the parent and the daughter radionuclides are the same elements. The 177mLu/177Lu radionuclide generator provides a new production route for the therapeutic radionuclide 177Lu and can bring significant growth in the research and development of 177Lu based pharmaceuticals.

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Section: Discussionmentioning

confidence: 99%

Separation of nuclear isomers for cancer therapeutic radionuclides based on nuclear decay after-effects

Bhardwaj

Meer

Das

et al. 2017

Sci Rep

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Preparation of Radionuclides

Luo

2023

Nuclear Science and Technology

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Fast flux spectrum unfolding of PFTS of KAMINI: an investigation into the viability of radioisotope production

Bagchi,

Chand,

Sen

et al. 2024

J Radioanal Nucl Chem

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The fast component (0.7–18 MeV) of the neutron spectrum at the Pneumatic Fast Transfer System (PFTS) in the KAMINI reactor was determined by irradiating threshold activation foils. The acquired reaction rates are subsequently unfolded using SAND-II code. The KAMINI reactor was modelled in the MCNP-4B code for an estimate of neutron spectrum at the PFTS location, which was subsequently used as the initial apriori solution for the SAND-II code. The unfolded fast component spectrum at the PFTS was found to be similar to that of the fast benchmark GODIVA and JEZEBEL-23. Moreover, the investigation is substantiated by incorporating modified spectra to estimate the theoretical yield of radioisotopes 32P at PFTS using a Monte Carlo simulation against its experimental yield. The results agree with an accuracy of 6%, affirming the credibility of the derived spectrum. Theoretical yields of 89Sr, 64Cu, and 47Sc were also estimated at the same location.

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Reactor-Produced Therapeutic Radionuclides

Cited by 3 publications

References 242 publications

Separation of nuclear isomers for cancer therapeutic radionuclides based on nuclear decay after-effects

Separation of nuclear isomers for cancer therapeutic radionuclides based on nuclear decay after-effects

Preparation of Radionuclides

Fast flux spectrum unfolding of PFTS of KAMINI: an investigation into the viability of radioisotope production

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