Ready Access to Densely Substituted Furans Using Tsuji–Wacker-Type Cyclization

Abstract

A competent method for the construction of highly substituted furans catalyzed by Pd­(II) and Cu­(II) chloride has been developed. The method provides easy access to di-, tri-, and tetrasubstituted furans from corresponding diols with relatively mild conditions in a unified strategy. The developed method has been successfully tested with more than 25 substrates, which resulted in furans of multiple substitution patterns with up to 84% isolated yields.

Amidative Cyclization of Alkynyl Esters to Access Pyrazin-1(2H)-ones: Application to the Synthesis of Peramine and Dibromophakellin

“…With the successful demonstration of our methodology, as part of our continuous interest in the total synthesis of biologically active natural products, this newly developed methodology was used. Bioactive natural products such as dibromophakellin and peramine (Figure ) were selected as appropriate targets to be achieved utilizing our methodology.…”