Despite the increasing importance of intersectoral collaborations to address crisis situations, relatively little is known about how they are organised, managed and governed. Moreover, within the field of public administration, there is still much to learn about how governments can use intersectoral collaboration to effectively address crises. This paper examines the case of the Coordinated Donor Support initiative in South Africa's COVID‐19 vaccination programme to illustrate the value of multisectoral partnerships, especially for developing countries. This partnership involved donors and philanthropic organisations, non‐governmental and civil society organisations, and private sector organisations, yet it sought to partner with the government, rather than take over the government's role. The paper also explores the complexities, contradictions and threats to such partnerships, and what is required to optimise them. It argues that several measures need to be put in place in the pre‐crisis phase to ensure that such multisectoral collaborations can quickly be mobilised when crises occur. It also shows that partnerships which are forged in times of crisis can assist countries to address their ongoing developmental challenges.