Loupy and co-workers prepared acetals of 1-galactono-1,4-lactone in excellent yields [32] by adsorbing the lactone and a long-chain aldehyde on montmorillonite K10 or KSF clay followed by exposure of the reaction mixture to MW irradiation (Scheme 10.1). Improvements over conventional methods are considerable (DMF, H 2 SO 4 , 24 h at 40 • C, yields less than 20-25%).MW, 10 min, 60-89% clay, RCHO