Reagin-like antibody mediated passive anaphylactic reaction in mouse peritoneal mast cells

Prouvost‐Danon, Annie; Peixoto, Junia M.; Javierre, M. Queiroz

doi:10.1016/0024-3205(67)90207-x

Cited by 14 publications

(17 citation statements)

References 12 publications

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“…from mast cell. [13][14][15][16] Although histamine is the major chemical mediator inducing itching, histamine did not induce scratching behavior in ddY mice as described in the previous paper. 1) CM-ext significantly inhibited compound 48/80-induced scratching behaviors of ddY mice without influence on spontaneous locomotion.…”

Section: Discussionsupporting

confidence: 54%

Antipruritic Effect of Cnidii Monnieri Fructus (Fruits of Cnidium monnieri CUSSON).

Matsuda

Ido

Hirata

et al. 2002

Biological & Pharmaceutical Bulletin

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Pruritus is discomfort cutaneous sensation for patients having a skin disorder such as atopic dermatitis, and is often accompanied by scratching behavior. Antihistaminic, steroid and antiallergic drugs are used for the treatment of pruritus. During the course of our studies seeking antipruritic agents from natural resources, we developed an experimental mice model to treat a number of samples in a short time to evaluate the antipruritic effect.1) Using this model, namely compound 48/80-induced scratching behavior in ddY-mice, several herb medicines whose antipruritic effect was expected from various herbal literature were screened. Among them, Kochiae Fructus (dried fruits of Kochia scoparia L.) and Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri CUSSON) were found to exhibit an antipruritic effect. Momordin Ic, an oleanane-type saponin, isolated from Kochiae Fructus was ascertained to be one of the active components. 1)Recently, Basnet et al.2) reported that a mixture of coumarin derivatives obtained from Cnidii Monnieri Fructus exhibited an antipruritic action on substance P-induced itching model ICR mice. However, inhibition of compound 48/80-induced scratching behavior in ddY mice by 70% ethanol extract (CM-ext) of Cnidii Monnieri Fructus has not been investigated in detail. The object of this report 3) is to examine the antipruritic components of CM-ext using compound 48/80-induced itching model mice. MATERIALS AND METHODS Plant Material Cnidii Monnieri Fructus (dried fruits ofCnidium monnieri CUSSON produced in China) was purchased from Yamada Yakken Co., Ltd. Pharmacy (Osaka) in 1999. A voucher specimen has been deposited at Kinki University, Osaka, (voucher number: CM-99001).Preparation of CM-ext from Cnidii Monnieri Fructus The crushed fruits (500 g) of Cnidium monnieri were extracted twice with 70% EtOH (5 l each) under reflux for 1 h. The combined filtrates were concentrated under reduced pressure and lyophilized to give a brown powder (CM-ext) (73.7 g, yield; 14.7%).Fractionation of CM-ext and Isolation of Osthol (1), Imperatorin (2), and Isopimpinellin (3) Melting points were determined on a Yanagimoto micro melting point apparatus without correction. All chemical reagents were reagent grade and were purchased from Wako Pure Chemical Industries, Ltd. (Osaka), unless otherwise noted. The CM-ext (53.7 g) was suspended in water and then extracted successively with hexane, EtOAc, and 1-BuOH. After solvent extraction, the aqueous layer was concentrated under reduced pressure and lyophilized to afford an aqueous soluble fraction (26.7 g) (Chart 1). The hexane extract was dried over Na 2 SO 4 and concentrated. The resulting crystalline precipitate (2.47 g) was collected by filtration, and its mother liquor was concentrated to give a hexane soluble fraction (3.9 g). The EtOAc extract was dried over Na 2 SO 4 and concentrated to give an EtOAc soluble fraction (9.9 g). The 1-BuOH extract was concentrated to give a 1-BuOH soluble fraction (3.9 g). Antipruritic activity of each fraction was assayed by...

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Section: Discussionsupporting

confidence: 54%

Antipruritic Effect of Cnidii Monnieri Fructus (Fruits of Cnidium monnieri CUSSON).

Matsuda

Ido

Hirata

et al. 2002

Biological & Pharmaceutical Bulletin

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“…Mice are a popular animal in laboratory studies concerning IgE (Prouvost-Danon et al, 1967). No specific IgE was isolated after L3 inoculation into the peritoneum of mice (Iglesias et al, 1993).…”

Section: Specific Immunoglobulin E Production and Allergy To L3mentioning

confidence: 99%

“…Total IgE levels at day 0, 1 mo, and 6 mo after exposure were found to be relatively similar. The use of an experimental animal model in the study of the kinetics of specific IgE and total IgE production provided useful data, which could not be readily obtained with humans.Mice are a popular animal in laboratory studies concerning IgE (Prouvost-Danon et al, 1967). No specific IgE was isolated after L3 inoculation into the peritoneum of mice (Iglesias et al, 1993).…”

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confidence: 99%

Immune reactions and allergy in experimental anisakiasis

Cho

Lee

2006

Korean J Parasitol

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Abstract:The third-stage larvae (L3) of the parasitic nematode, Anisakis simplex, have been implicated in the induction of hyperimmune allergic reactions in orally infected humans. In this work, we have conducted a review of an investigation into immune reactions occurring in animals experimentally infected with A. simplex L3. The patterns of serum antibody productions in the experimental animals against excretory-secretory products (ESP) of A. simplex L3 contributed to our current knowledge regarding specific humoral immune reactions in humans. In our review, we were able to determine that L3 infection of experimental animals may constitute a good model system for further exploration of immune mechanisms and allergy in anisakiasis of humans. worldwide (Mattiucci et al., 1997;Shih, 2004;Ugland et al., 2004). Many epidemics have been reported in Japan and Spain (Chai et al., 2005). Increasing reports of L3 infection in fish have been documented in South Korea, in which the consumption of raw marine fish is also popular (Chai et al., 1992;Im et al., 1995;Song et al., 1995Song et al., , 1999. Easy access to endoscopes and enhanced awareness of anisakiasis among clinicians has resulted in better reporting of morbidity resultant from L3 infection. L3 infection induces the production of specific antibodies and cytokines (Kennedy et al., 1988;Daschner et al., 2001;Nieuwenhuizen et al., 2006). Antibodies can be detected 2 weeks after infection, consistent with the time courses associated with other microorganisms. Analyses of specific antibody levels are generally irrelevant to the differential diagnosis of an acute state in cases of L3 infection, because the profound pain associated with L3 penetration begins only a few hours after the consumption of infected raw fish. However, antibody level measurements are helpful both in the differentiation of tumors from the granulomas formed by infiltrating L3 and in investigations of allergic diseases (Gutierrez and Cuellar, 2002;Kim et al., 2006).The production of IgE tends to increase during parasite infections, but the ultimate effects of IgE vary considerably, depending on the host-parasite relationships. Hyperimmune allergic reactions have been closely associated with IgE production. The infection of a parasite into its normal host tends to reduce the development of allergic responses, despite the associated upshift in IgE production (van den Biggelaar et al., 2000;Yazdanbakhsh et al., 2002). By contrast, the infection of T. canis in humans, an abnormal host, induces increased allergic reactions (Sharp and Olson, 1962;Sharghi et al., 2001). A. simplex L3 has also been shown to induce allergic diseases at a high rate, principally due to the fact that humans are not a regular host of this parasite (Audicana et al., 2002;Klimpel et al., 2004).Through investigations of allergic responses to L3 for a period of more than 10 years, several shared features have been identified, which indicate that immune reactions to L3 infection evidence similar patterns in humans and experimental...

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“…Mouse mast cells are not capable of in vitro sensitization with unfractionated antiserum containing IgE-like antibody; however, in vivo administration of such anti sera into normal mice sensitizes their mast cells for histamine release [17]From the results cited, it would appear that the heat labile homocyto tropic antibody of the rabbit reacts similarly to that of the mouse. All at tempts to sensitize rabbit leukocytes in vitro with antiserum demonstrat ing homocytotropic antibody resulting in histamine release from platelets have been unseccessful.…”

Section: Discussionmentioning

confidence: 99%

“…Although the ability to passively sensitize human leukocytes [15], rat mast cells [3,14], and mouse mast cells [16,17] with their respective heat labile homocytotropic antibody has been demonstrated, the passive sensitization of rabbit leukocytes has not been described. This report de scribes the in vivo passive sensitization of normal rabbit leukocytes with sera having homocytotropic antibodies.…”

mentioning

confidence: 99%

<i>In vivo</i> Passive Sensitization of Normal Rabbit Leukocytes with Sera Demonstrating Homocytotropic Antibody Activity

Colwell¹,

Ortaldo²,

Schoenbechler³

et al. 1971

Int Arch Allergy Immunol

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Normal rabbit leukocytes were passively sensitized, as determined by in vitro antigen-induced histamine release, by the i.v. administration of homologous sera demonstrating homocytotropic antibody activity. There was a significant correlation between the magnitude of passive sentization and the PCA titers of the donor sera. Those parameters that affected skin sensitization also affected leukocyte sensitization. Maximal leukocyte sensitization was observed 3 days after serum administration and by the 10th day no significant histamine release was demonstrable.

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Reagin-like antibody mediated passive anaphylactic reaction in mouse peritoneal mast cells

Cited by 14 publications

References 12 publications

Antipruritic Effect of Cnidii Monnieri Fructus (Fruits of Cnidium monnieri CUSSON).

Antipruritic Effect of Cnidii Monnieri Fructus (Fruits of Cnidium monnieri CUSSON).

Immune reactions and allergy in experimental anisakiasis

<i>In vivo</i> Passive Sensitization of Normal Rabbit Leukocytes with Sera Demonstrating Homocytotropic Antibody Activity

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