Our whole body is affected by the passage of time, and facial aging in particular is the focus of cosmetic treatments. At the subdermal level, loss of collagen and adipose tissue cause structural changes characterized by fine lines, increased wrinkle formation, grooves, and depressions. Facial aging is not only caused by loss of adipose tissue and skin defects, facial muscles, and bones also contribute to this natural process. 1 Loss of collagen is one of the characteristics of aging, but other important components of the skin, such as hyaluronic acid (HA), also undergo critical changes. 2 A deeper understanding of aging in each