The development of myeloid malignancies is a multi-step process starting from pre-malignant stages. Large-scale studies on clonal hematopoiesis of indeterminate potential (CHIP) identified this condition as a risk factor for developing hematologic malignancies, in particular
myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). In parallel, CHIP was
found to confer an enhanced thrombotic risk, in particular for cardiovascular diseases. In a similar
fashion, in recent years, alongside their life-threatening features, increasing attention has been
drawn toward thrombotic complications in myeloid malignancies. Thus, the purpose of this review is to gather a growing body of evidence on incidence, pathogenesis and clinical impact of
thrombosis in myeloid malignancies at every step of malignant progression, from CHIP to AML.