Real Life Lessons in Peripheral Artery Disease - A Priority for Public Healthcare

Ricco, Jean-Baptiste; Aboyans, Victor; Dick, Florian; Kolh, Philippe

doi:10.1016/j.ejvs.2019.12.003

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…[4][5][6][7] It causes structural and functional changes in the limbs, leading to disability, reduced quality of life, high mortality, and substantial economic burden. [8][9][10] Patients with PAD have a three to six times increased risk of cardiovascular mortality (myocardial infarction and stroke) compared to those without PAD 11 and patients with severe symptomatic large-vessel PAD have a 25% chance of death by vascular causes within 12 months. 12 The vasculature of the eye and the heart share several common characteristics and because the blood vessels of the eye are easily amenable to examination, they can to some extent serve as a window to the heart.…”

Section: Introductionmentioning

confidence: 99%

Role of noninvasive ocular imaging as a biomarker in peripheral artery disease (PAD): A systematic review

Prem Senthil,

Kurban,

Thuy Nguyen

et al. 2023

Vasc Med

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This study aimed to review the current literature exploring the utility of noninvasive ocular imaging for the diagnosis of peripheral artery disease (PAD). Our search was conducted in early April 2022 and included the databases Medline, Scopus, Embase, Cochrane, and others. Five articles were included in the final review. Of the five studies that used ocular imaging in PAD, two studies used retinal color fundus photography, one used optical coherence tomography (OCT), and two used optical coherence tomography angiography (OCTA) to assess the ocular changes in PAD. PAD was associated with both structural and functional changes in the retina. Structural alterations around the optic disc and temporal retinal vascular arcades were seen in color fundus photography of patients with PAD compared to healthy individuals. The presence of retinal hemorrhages, exudates, and microaneurysms in color fundus photography was associated with an increased future risk of PAD, especially the severe form of the disease. The retinal nerve fiber layer (RNFL) was significantly thinner in the nasal quadrant in patients with PAD compared to age-matched healthy individuals in OCT. Similarly, the choroidal thickness in the subfoveal region was significantly thinner in patients with PAD compared to controls. Patients with PAD also had a significant reduction in the retinal and choroidal circulation in OCTA compared to healthy controls. As PAD causes thinning and ischemic changes in retinal vessels, examination of the retinal vessels using retinal imaging techniques can provide useful information about early microvascular damage in PAD. Ocular imaging could potentially serve as a biomarker for PAD.

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Section: Introductionmentioning

confidence: 99%

Role of noninvasive ocular imaging as a biomarker in peripheral artery disease (PAD): A systematic review

Prem Senthil,

Kurban,

Thuy Nguyen

et al. 2023

Vasc Med

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“…Peripheral artery disease (PAD) is a common vascular disease involving major structural and functional changes of the lower limbs’ arterial circulation, leading to disability, a marked decline in quality of life, and high mortality with a substantial economic burden [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. Presently, the prevalence of PAD is steadily growing, accounting for 2–10% of the general population and up to 20% of patients are over 70 years of age.…”

Section: Introductionmentioning

confidence: 99%

Biomarker Utility for Peripheral Artery Disease Diagnosis in Real Clinical Practice: A Prospective Study

et al. 2020

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Peripheral arterial disease (PAD) is a common manifestation of generalized atherosclerosis, which affects more than 200 million patients worldwide. Currently, there is no ideal biomarker for PAD risk stratification and diagnosis. The goal of this research was to investigate the levels of inflammation biomarkers and cystatin C and to explore their utility for the diagnosis of PAD. The study included 296 participants, distributed in two groups: 216 patients diagnosed with PAD and 80 patients without PAD as controls. All studied biomarker levels (C-reactive protein, CRP; fibrinogen; erythrocyte sedimentation rate, ESR; neopterin; beta 2-microglobulin, B2-MG; and cystatin C) were significantly higher in the PAD group and indirectly correlated with the ankle–brachial index (ABI). The final logistic regression model included an association of neopterin, fibrinogen, and cystatin C as the most efficient markers for the prediction of PAD diagnosis. When comparing the area under the curve (AUC) for all biomarkers, the value for neopterin was significantly higher than those of all the other analyzed biomarkers. In agreement with previous studies, this research shows that markers such as fibrinogen, CRP, ESR, B2-MG, and cystatin C have significant value for the diagnosis of PAD, and also clearly underlines the accuracy of neopterin as a leading biomarker in PAD prediction.

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Real Life Lessons in Peripheral Artery Disease - A Priority for Public Healthcare

Cited by 2 publications

References 13 publications

Role of noninvasive ocular imaging as a biomarker in peripheral artery disease (PAD): A systematic review

Role of noninvasive ocular imaging as a biomarker in peripheral artery disease (PAD): A systematic review

Biomarker Utility for Peripheral Artery Disease Diagnosis in Real Clinical Practice: A Prospective Study

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