Real‐life observational cohort verifies high efficacy of dupilumab for chronic rhinosinusitis with nasal polyps

Abstract

et al. Modified oral food challenge used with sensitization biomarkers provides more reallife clinical thresholds for peanut allergy.

Biologicals and Endoscopic Sinus Surgery for Severe Uncontrolled Chronic Rhinosinusitis With Nasal Polyps: An Economic Perspective

“…Dosage intervals were increased stepwise every 6 months even up to one injection every 8 weeks, while maintaining the same level of disease control. 36 Reducing costs and the emergence of biosimilars will also enhance costeffectiveness. It is implicit that analyses should be repeated if costs or evidence for the clinical effectiveness of each strategy change substantially.…”

“…On the other hand, real-life data report a level of disease control that is unprecedented in the group of severe, uncontrolled patients with CRSwNP. 36 Therefore, different approaches to reducing the cost and optimizing the use of biologic therapy should be developed and studied.…”

“…This reduced direct costs by at least a factor of three. 36 Another approach that we have anecdotally encountered is the temporary use of biologics as rescue medication, much in the same way as a short course of OCS. To our knowledge, no data have been published on the clinical or cost-effectiveness of such an approach.…”

“…In some countries, previous ESS with at least a full ethmoidectomy is mandatory before one can start biologics, although this surgery typically is from previous years and not simultaneous with the start of biologics. 36 For now, specific traits such as asthma and especially AERD/ N-ERD might favor selection for biologic treatment, because options for AERD/N-ERD fall short in providing long-term disease control. 6 Ideally, progressive insight into the pathophysiologic processes underlying type 2 CRS will lead to the development of clinically applicable biomarkers that can predict treatment outcomes for both ESS and biologics.…”

Unmet needs in biological treatment of CRS

“…The results of treatment with biologicals are spectacular, especially on smell and quality of life. In real life, polyps often disappear after treatment with biological in most patients (2) . However, the treatment is very costly (3) .…”