Real-life safety study of an accelerated cluster immunotherapy with a house dust mite native extract in patients with allergic rhinitis or rhinoconjunctivitis

Effect of Loratadine Tablets in Combination with Other Drugs on Nasal Physiological Function and T Lymphocyte Subsets in Patients with Allergic Rhinitis

“…(1) ose who have taken H1antihistamines, steroids, AH, decongestants directly acting on the eyes, nose and mouth, corticosteroids, antibiotics, and other drugs within 14 days before treatment; those who have received SLIT, SCIT immunotherapy, or hormone system therapy in the last year. ose, who received physiotherapy in traditional Chinese medicine and other traditional Chinese medicine fields such as acupuncture, moxibustion, cupping, inhalation of traditional Chinese medicine and other traditional Chinese medicine within 14 days before treatment; those who had taken proprietary medicine or decoction that had a significant effect on AR within 14 days before treatment, or those who could not be treated with acupuncture; (2) other types of rhinitis not caused by AR, such as runny nose, stuffy nose, sneezing, itching and ant sensation; (3) patients with respiratory infection within 14 days before enrollment, chronic paranasal sinusitis in previous history or chronic paranasal sinusitis demonstrated by X-ray examination of paranasal sinuses, nasal polyps, severe deviation of nasal septum, severe organic lesions in nasal cavity or undergoing surgery, patients with a history of respiratory diseases; (4) Asthma or vasomotor rhinitis; (5) Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine and cystatin C (CysC) >1.5 times the upper limit of normal value; (6) there are serious primary diseases such as cardiovascular, liver, kidney, lung and blood, or serious diseases such as tumor and AIDS; (7) pregnant, lactating women, or persons with physical and mental disabilities; (8) by asking patients to identify those, who have used alcohol, hormone drugs and other medical history, or through the analysis of researchers, the probability of joining the group is low and the situation of joining the group is complicated; (9) patients, who have recently participated in other clinical drug studies; (10) there are people, who are allergic to the ingredients used in this study; and (11) those, who have joined the clinical trials of drugs in the past three months.…”

“…When Nrf2 binds to its corresponding inhibitory protein, ubiquitin degradation leads to a decrease in its activity. When the body is subjected to stress, reactive oxygen species can make nuclear factor E2related factor 2 enter the nucleus, initiate HO-1 transcription and expression, inhibit NF-κ B signal pathway, and play an antioxidant role [7]. Regulatory T cells (Treg) are a class of T cells that express CD4, CD25, and transcription factor Foxp3.…”