The paper proposes a novel predictive-reactive planning and scheduling framework in which both approaches are combined to complement each other in a reasonably balanced way. Neither original scheduling algorithms nor original techniques can be find in this paper. It also does not intend to invent new mechanisms or to propose some cardinally new ideas. The aim is to choose, adapt and test ideas, mechanisms and algorithms already proposed by other researchers. The focus of this research is set on make-to-order production environments. The proposed approach aims not only to absorb disruptions in shop floor level schedules but also to mitigate the impacts of potential exceptions, which disrupt mid-term level production plans. It is based on application of risk mitigation techniques and combines various simulation techniques extended by optimization procedures. The proposed approach is indented to be implemented in Advanced Planning and Scheduling system, which is an add-on for Enterprise Resources Planning system. To make it easier to understand the focus of the paper, at the beginning the position from which we start is clarified.