The aim of this paper is to introduce and to study the space $${{\mathcal {O}}}_{M,\omega }({{\mathbb {R}}}^N)$$
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of the multipliers of the space $${{\mathcal {S}}}_\omega ({{\mathbb {R}}}^N)$$
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of the $$\omega $$
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-ultradifferentiable rapidly decreasing functions of Beurling type. We determine various properties of the space $${{\mathcal {O}}}_{M,\omega }({{\mathbb {R}}}^N)$$
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. Moreover, we define and compare some lc-topologies of which $${{\mathcal {O}}}_{M,\omega }({{\mathbb {R}}}^N)$$
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can be naturally endowed.