Real-time 3D-echocardiography of the right ventricle—paediatric reference values for right ventricular volumes using knowledge-based reconstruction: a multicentre study

Herberg, Ulrike; Smit, F.; Winkler, Christian; Dalla‐Pozza, Robert; Breuer, Johannes; Laser, Kai Thorsten

doi:10.21037/qims-20-1155

Cited by 5 publications

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are many imaging modalities available to assess cardiac morphology and function ( 25 , 26 ). TEE is the most widely used and accepted method to evaluate LAA function and the risk of thromboembolism.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with left atrial appendage filling defects on early-phase cardiac computed tomography in patients with nonvalvular atrial fibrillation: a case-control study

Liu¹,

Tian²,

Hu³

et al. 2023

Quant Imaging Med Surg

View full text Add to dashboard Cite

Background: The significance of left atrial appendage (LAA) filling defects on early-phase cardiac computed tomography (CCT) remains uncertain. This study retrospectively investigated predictive factors of LAA filling defects on early-phase CCT.Methods: A total of 68 patients with nonvalvular atrial fibrillation (AF) and early filling defect on CCT who underwent transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) were enrolled [48 males, 20 females; mean ± standard deviation (SD) age 62.72±8.13 years]. Additionally 68 sexand age-matched patients with normal LAA filling were included as the control group. CCT, ultrasound, clinical and laboratory data were analyzed. Baseline data between groups were analyzed using t-, Mann-Whitney, and chi-squared tests. Multivariable logistic regression analysis was used to adjust for confounders.Pearson correlation analysis was used to confirm correlations between variables.Results: Decreased LAA flow velocity [LAAFV; odds ratio (OR) =0.918; 95% confidence interval (CI): 0.883-0.954; P<0.001] and increased left atrial volume index (LAVI; OR =1.055; 95% CI: 1.012-1.099; P=0.011) were significantly associated with early-phase CCT LAA filling defects. The LAAFV threshold for predicting early LAA filling defects was 40.5 cm/s, with an area under the receiver operating characteristic (ROC) curve (AUC) of 0.905 (sensitivity 82.4%, specificity 91.2%); the LAVI predictive threshold was 58.77 mL/m 2 (AUC =0.840, sensitivity 85.3%, specificity 72.1%). A significant positive correlation was detected between LAAFV and the Hounsfield unit (HU) ratio of the LAA to ascending aorta on early-phase CCT (r=0.614; P<0.001), as well as the HU difference in LAA between early and delayed phase CCT (r=0.591; P<0.001). There were significant (P<0.05) differences in LAAFV between different filling defects.Conclusions: Decreased LAAFV and increased LAVI are independent factors associated with LAA filling defects only on early-phase CCT. Early-phase CCT LAA filling defect is associated with LAA emptying dysfunction. These findings contribute to thrombosis risk stratification in patients with AF.

show abstract

Section: Discussionmentioning

confidence: 99%

Factors associated with left atrial appendage filling defects on early-phase cardiac computed tomography in patients with nonvalvular atrial fibrillation: a case-control study

Liu¹,

Tian²,

Hu³

et al. 2023

Quant Imaging Med Surg

View full text Add to dashboard Cite

show abstract

“…Multiple imaging modalities are available to assess cardiac morphology and function ( 6 ). Echocardiography is a widely used means of non-invasively assessing cardiac anatomy ( 7 ). Transesophageal ultrasound is the “gold standard” for diagnosing thrombus in LAA ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Morphological changes in the orifices of the left atrial appendage and left atrium in patients with atrial fibrillation

Tian¹,

Wang²,

Gao³

et al. 2022

Quant Imaging Med Surg

View full text Add to dashboard Cite

Background: As an integral part of the left atrium (LA), the left atrial appendage (LAA) plays an important role in atrial fibrillation (AF). However, the relationship between LAA remodeling and AF has not been clearly defined. This retrospective case-control study aimed to assess the morphological and functional features of the LA and the LAA in AF patients using images obtained by computed tomography angiography (CTA).Methods: A total of 140 AF patients and 64 patients without AF or other cardiovascular diseases who underwent CTA scans between September 2016 and August 2017 were enrolled in this observational study as the experimental and the control groups, respectively. The major and minor axes, area, and perimeter of the LAA orifice, the LAA depth, and the volume of both the LAA and LA were analyzed. The data of the AF group and the control group were compared. The t-test was used to analyze the normally distributed data, and the Wilcoxon rank-sum test was used for abnormally distributed data. The best critical value of predictors of AF was calculated using receiver operating characteristic (ROC) curve analysis. The correlation of the LAA volume change with the major and minor axes, area, and perimeter of the LAA orifice, and the LAA depth were analyzed using the Pearson correlation coefficient. Results:The LAA orifice's minor axis, LAA volume, and LA volume were significantly greater (P=0.004, P=0.010, and P<0.001, respectively) in patients with AF than in those without AF. The LAA volume [95% confidence interval (CI): 1.01 to 1.30; P=0.038] and LA volume (95% CI: 1.03 to 1.07; P<0.001) were significantly independent predictors of AF. An LAA volume of 8.75 mL had the highest predictive value for AF [area under the curve (AUC), 0.612], with a sensitivity of 76.6% and a specificity of 48.6%. In contrast, an LA volume of 97.15 mL had the highest predictive value for AF (AUC, 0.771), with a sensitivity of 90.6% and a specificity of 53.6%. The change of LAA volume was positively weakly correlated with the area and perimeter of the LAA orifice (r=0.1703 and r=0.1378, respectively). The LAA emptying fraction was negatively correlated with the major axis and the area of the LAA orifice. The major and minor axes, area, and perimeter of the LAA orifice, and LAA depth were significantly greater in female than in male patients (P=0.003, P=0.003, P=0.001, P=0.019, and P<0.001, respectively). Conclusions:The AF patients had a longer minor axis of the LAA orifice than that of the control group, resulting in a more circular LAA orifice. The LAA orifice area and perimeter were positively correlated with LAA volume change. The LAA orifice major and minor axes, area, and perimeter, and the LAA depth of the female patients were significantly greater than those of their male counterparts in AF patients.

show abstract

“…Follow-up of patients after ASO includes serial echocardiographic studies to evaluate LV and AA remodeling. This remodeling process can lead to changes in ventricular geometry, wall thickness, and chamber size, potentially impacting cardiac mechanics [19,20].…”

Section: Cardiac Mechanics In the Aortic Arch Anomaliesmentioning

confidence: 99%

Unveiling the gothic aortic arch and cardiac mechanics: insights from young patients after arterial switch operation for d-transposition of the great arteries

Pergola,

Avesani,

Reffo

et al. 2023

Monaldi Arch Chest Dis

View full text Add to dashboard Cite

The arterial switch operation (ASO) has become the standard surgical treatment for patients with d-transposition of the great arteries (d-TGA). While ASO has significantly improved survival rates, a subset of patients develops a unique anatomical anomaly known as the gothic aortic arch (GAA). Understanding cardiac mechanics in this population is crucial as altered mechanics can have profound consequences on cardiac function and exercise capacity. The GAA has been associated with changes in ventricular function, hemodynamic, and exercise capacity. Studies have shown a correlation between the GAA and decreased ascending aorta distensibility, loss of systolic wave amplitude across the aortic arch, and adverse cardiovascular outcomes. Various imaging techniques, including echocardiography, cardiac magnetic resonance imaging (CMR), and cardiac computed tomography (CCT), play a crucial role in assessing cardiac mechanics and evaluating the GAA anomaly. Despite significant advancements, gaps in knowledge regarding the prognostic implications and underlying mechanisms of the GAA anomaly remain. This review aims to explore the implications of the GAA anomaly on cardiac mechanics and its impact on clinical outcomes in young patients after ASO. Advancements in imaging techniques, such as computational modeling, offer promising avenues to enhance our understanding of cardiac mechanics and improve clinical management.

show abstract

Real-time 3D-echocardiography of the right ventricle—paediatric reference values for right ventricular volumes using knowledge-based reconstruction: a multicentre study

Cited by 5 publications

References 44 publications

Factors associated with left atrial appendage filling defects on early-phase cardiac computed tomography in patients with nonvalvular atrial fibrillation: a case-control study

Factors associated with left atrial appendage filling defects on early-phase cardiac computed tomography in patients with nonvalvular atrial fibrillation: a case-control study

Morphological changes in the orifices of the left atrial appendage and left atrium in patients with atrial fibrillation

Unveiling the gothic aortic arch and cardiac mechanics: insights from young patients after arterial switch operation for d-transposition of the great arteries

Contact Info

Product

Resources

About