Real-time breast sonography: application in 300 consecutive patients

Hilton, Sarah A.; Leopold, George R.; Olson, Lynn; Willson, S. A.

doi:10.2214/ajr.147.3.479

Cited by 126 publications

(50 citation statements)

References 2 publications

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“…The use of ultrasonography (US) as an adjunct to conventional mammography decreases the number of benign biopsy results by enabling reliable differentiation of simple cysts from solid lesions (2)(3)(4). The US features of a solid lesion alone, however, are frequently not reliable enough to obviate biopsy (5,6).…”

Section: Fwhm = Full Width At Half Maximummentioning

confidence: 99%

Benign versus Malignant Breast Masses: Optical Differentiation with US-guided Optical Imaging Reconstruction

Zhu¹,

Cronin²,

Currier³

et al. 2005

Radiology

190

185

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PURPOSE-To investigate prospectively the feasibility of using optical tomography with ultrasonographic (US) localization to differentiate malignant from benign breast masses and to compare optical tomography with color Doppler US. MATERIALS AND METHODS-The study was approved by the local internal review board committee and by the Human Subjects Research Review Board of Army Medical Research and Materiel Command. Signed informed consent was obtained, and the study was HIPAA compliant. Between May 2003 and March 2004, 65 consecutive women (mean age, 51 years; age range, 24-80 years) with 81 breast lesions underwent US-guided biopsy and were scanned with a combined imager. The hand-held probe, which consisted of a centrally located US transducer surrounded by nearinfrared sensors, was used to simultaneously acquire coregistered US images and optical data. The lesion location obtained at US was used to guide optical imaging reconstruction. Light absorption was measured at two wavelengths. From these measurements, tumor angiogenesis was assessed on the basis of calculated total hemoglobin concentration. A Student t distribution was used to calculate the statistical significance of mean maximum and mean average hemoglobin concentrations obtained in malignant and benign lesion groups, and P < .001 was considered to indicate a statistically significant difference.RESULTS-Biopsy results revealed eight early stage invasive carcinomas (malignant group) and 73 benign lesions (benign group). The mean maximum and mean average hemoglobin concentrations in the malignant group were 122 μmol/L ± 26.8 (± standard deviation) and 88 μmol/L ± 24.5, respectively. The mean maximum and mean average hemoglobin concentrations in the benign group were 55 μmol/L ± 24.8 and 38 μmol/L ± 17.4, respectively. Both the maximum and average total hemoglobin concentrations were significantly higher in the malignant group compared with the benign group (P < .001). When a maximum hemoglobin concentration of 95 μmol/L was used as the threshold value, the sensitivity, specificity, positive predictive value, and negative predictive value of optical tomography were 100%, 96%, 73%, and 100%, respectively, and the sensitivity, specificity, positive predictive value, and negative predictive value of color Doppler US were 63%, 69%, 19%, and 94%, respectively. Tumor angiogenesis is known to be critical for the autonomous growth and spread of breast cancers (7,8). Tumor angiogenesis is a complex process that involves both the incorporation of existing host blood vessels into the tumor and the creation of tumor microvessels. This process is moderated by means of tumor angiogenesis factors (9). In principle, the altered hemodynamics that accompany tumor angiogenesis provide a basis for discriminating between malignant and benign breast masses at color Doppler US (10). The diagnostic value of color Doppler US in obviating biopsy, however, has been limited (11,12).Optical tomography, a new technique that employs diffused light in the near-infrared spectrum...

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Section: Fwhm = Full Width At Half Maximummentioning

confidence: 99%

Benign versus Malignant Breast Masses: Optical Differentiation with US-guided Optical Imaging Reconstruction

Zhu¹,

Cronin²,

Currier³

et al. 2005

Radiology

190

185

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“…According to literature cysts are very common finding in women during the involution phase (35-50 years). Simple cysts are characterized with 100% accuracy [7], [8] as long as they are not too small (< 5 mm in size) or not too deep. Fibroadenomas are more common before 25 to 30 years of age and it is the most common benign tumor of female breast.…”

Section: Discussionmentioning

confidence: 99%

Differentiation of Benign and Malignant Breast Lesions Based on Ultrasound Criteria

K¹

2017

jmscr

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“…Conversely, posterior enhancement may be absent in approximately 15% of cysts if they are deeply located, as a result of acoustic attenuation by adjacent muscle and cartilage. 2,5 Abscesses accounted for 12% (7 of 57) of the lesions. Abscess formation is usually a complication of suppurative mastitis.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] Although the specificity of various sonographic patterns has been reported in breast masses in adults, similar data are lacking in pediatric patients. Previous series have included small numbers of children 6 or were primarily performed with older technology.…”

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confidence: 99%

Gray scale sonography of breast masses in adolescent girls.

Kronemer

Rhee

Siegel

et al. 2001

J of Ultrasound Medicine

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Objective. To assess the sonographic findings of breast masses in adolescents and the usefulness of sonographic patterns for suggesting a specific diagnosis. Methods. The sonograms and medical records of 57 girls (mean age, 15.4 years) with palpable breast masses were retrospectively reviewed. Three observers reviewed the sonograms for multiple sonographic findings. Surgery or clinical findings established diagnoses. Statistical analysis was done to determine how well sonographic findings alone and in combination agreed with final histologic diagnoses. Results. Diagnoses included cysts (n = 12), abscesses (n = 7), fibroadenomas (n = 36), a lactating adenoma (n = 1), and a phyllodes tumor (n = 1). The sonographic findings varied significantly among lesion types (P ≤ .005). Conclusions. Our experience suggests that virtually all breast masses in a pediatric population are benign and that sonography has the ability to differentiate among cystic, inflammatory, and solid masses. Key words: sonography; breast; mass; adolescent. onography has become a widely used modality for characterizing breast masses in adults as cystic or solid, and it has been shown to be highly reliable for this purpose. [1][2][3][4][5] Although the specificity of various sonographic patterns has been reported in breast masses in adults, similar data are lacking in pediatric patients. Previous series have included small numbers of children 6 or were primarily performed with older technology. 7 In view of the advances in technology and the development of high-frequency transducers, a reevaluation of the role of sonography in the clinical evaluation of the pediatric breast is appropriate. We thus undertook this study to determine whether there are gray scale sonographic findings that are helpful in differentiating breast masses in adolescents.

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Real-time breast sonography: application in 300 consecutive patients

Cited by 126 publications

References 2 publications

Benign versus Malignant Breast Masses: Optical Differentiation with US-guided Optical Imaging Reconstruction

Benign versus Malignant Breast Masses: Optical Differentiation with US-guided Optical Imaging Reconstruction

Differentiation of Benign and Malignant Breast Lesions Based on Ultrasound Criteria

Gray scale sonography of breast masses in adolescent girls.

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