Real‐Time Cerebral Hemodynamic Response to Tactile Somatosensory Stimulation

Hage, Benjamin; Way, E. Leong; Barlow, Steven M.; Bashford, Gregory R.

doi:10.1111/jon.12546

Cited by 9 publications

(8 citation statements)

References 37 publications

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“…18,24 A two-minute window was used for associating detected HITS with specific surgical maneuvers, based on previous transient analysis of CBFV signals. 25 Following the methods of Clark et al, 16 associated HITS counts were obtained by summing all identified HITS from the time of a surgical maneuver's occurrence to two minutes after the maneuver's occurrence (see subsequently for list of maneuvers). If two maneuvers occurred within less than two minutes, only HITS detected in the period between the first and second maneuvers were counted for the first maneuver.…”

Section: High-intensity Transient Signal Detection and Processingmentioning

confidence: 99%

Most High-Intensity Transient Signals Are Not Associated With Specific Surgical Maneuvers

Twedt

Hage

Hammel

et al. 2020

World J Pediatr Congenit Heart Surg

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Background: Mortality after congenital heart defect surgery has dropped dramatically in the last few decades. Current research on long-term outcomes has focused on preventing secondary neurological sequelae, for which embolic burden is suspected. In children, little is known of the correlation between specific surgical maneuvers and embolic burden. Transcranial Doppler ultrasound is highly useful for detecting emboli but has not been widely used with infants and children. Methods: Bilateral middle cerebral artery blood flow was continuously monitored from sternal incision to chest closure in 20 infants undergoing congenital heart defect repair or palliative surgery. Embolus counts for specific maneuvers were recorded using widely accepted criteria for identifying emboli via high-intensity transient signals (HITS). Results: An average of only 13% of all HITS detected during an operation were correlated with any of the surgical maneuvers of interest. The highest mean number of HITS associated with a specific maneuver occurred during cross-clamp removal. Cross-clamp placement also had elevated HITS counts that significantly differed from other maneuvers. Conclusions: In this study of infants undergoing cardiac surgery with cardiopulmonary bypass, the great majority of HITS detected are not definitively associated with a specific subset of surgical maneuvers. Among the measured maneuvers, removal of the aortic cross-clamp was associated with the greatest occurrence of HITS. Future recommended research efforts include identifying and confirming other sources for emboli and longitudinal outcome studies to determine if limiting embolic burden affects long-term neurological outcomes.

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Section: High-intensity Transient Signal Detection and Processingmentioning

confidence: 99%

Most High-Intensity Transient Signals Are Not Associated With Specific Surgical Maneuvers

Twedt

Hage

Hammel

et al. 2020

World J Pediatr Congenit Heart Surg

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“…The use of sensory input to facilitate adaptive functional neuroplasticity and sensorimotor function, which are primary goals for incorporating taste stimulation into dysphagia rehabilitation, has been well-established using other modalities. For example, repetitive sensory stimulation (RSS) has been associated with rapid increases of blood flow to sensorimotor brain areas [ 63 ]. Further, RSS has been reported to quickly evoke structural and functional neuroplasticity in sensory networks [ 64 , 65 ], and to increase accuracy of skilled movements when applied prior to task performance [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Comparing Taste Perception Across Modalities in Healthy Adults: Liquids Versus Dissolvable Taste Strips

Westemeyer

Dietsch

2023

Dysphagia

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Taste stimulation has rehabilitative value in dysphagia management, as it activates salient underlying afferent pathways to swallowing which may evoke feedforward effects on swallow biomechanics. Despite its potential beneficial effects on swallow physiology, taste stimulation’s clinical application is limited for persons unsafe to orally consume food/liquid. This study aimed to create edible, dissolvable taste strips matched to flavor profiles previously used in research assessing taste’s effects on swallowing physiology and brain activity, and to evaluate how similar their perceived intensity and hedonic, or palatability, ratings were between their liquid counterparts. Plain, sour, sweet–sour, lemon, and orange flavor profiles were custom-made in taste strips and liquid modalities. The generalized Labeled Magnitude Scale and hedonic generalized Labeled Magnitude Scale were used to assess intensity and palatability ratings for flavor profiles in each modality. Healthy participants were recruited and stratified across age and sex. Liquids were rated as more intense than taste strips; however, there was no difference in palatability ratings between the modalities. There were significant differences across flavor profiles in intensity and palatability ratings. Collapsed across liquid and taste strip modalities, pairwise comparisons revealed all flavored stimuli were rated as more intense than the plain profile, sour was perceived as more intense and less palatable than all other profiles, and orange was rated as more palatable than sour, lemon, and plain tastants. Taste strips have useful implications for dysphagia management, as they could offer safe and patient-preferred flavor profiles to potentially provide advantageous swallowing and neural hemodynamic responses.

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“…Therefore, the inclusion of short-separation channels for regressing out the extracerebral HR can improve the reliability and accuracy of such experiments. Furthermore, physiological monitoring with a minimal array of EEG electrodes to monitor participant status (i.e., alert, drowsy, sleep) is advisable, as state control can significantly affect cerebral process mechanisms, including HR and blood flow dynamics during somatosensory encoding and motor control [48].…”

Section: Discussionmentioning

confidence: 99%

Classification of Tactile and Motor Velocity-Evoked Hemodynamic Response in Primary Somatosensory and Motor Cortices as Measured by Functional Near-Infrared Spectroscopy

et al. 2020

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Functional near-infrared spectroscopy (fNIRS) is an emerging technique in studying cerebral hemodynamics; however, consensus on the analysis methods and the clinical applications has yet to be established. In this study, we demonstrate the results of a pilot fNIRS study of cerebral hemodynamic response (HR) evoked by pneumotactile and sensorimotor stimuli on the dominant hand. Our goal is to find the optimal stimulus parameters to maximally evoke HR in the primary somatosensory and motor cortices. We use a pulsatile pneumatic array of 14 tactile cells that were attached to the glabrous surface of the dominant hand, with a patterned stimulus that resembles saltation at three distinct traverse velocities [10, 25, and 45 cm/s]. NIRS optodes (16 sources; 20 detectors) are bilaterally and symmetrically placed over the pre-and post-central gyri (M1 and S1). Our objective is to identify the extent to which cerebral HR can encode the velocity of the somatosensory and/or motor stimuli. We use common spatial pattern for feature extraction and regularized-discriminant analysis for classifying the fNIRS time series into velocity classes. The classification results demonstrate discriminatory features of the fNIRS signal from each distinct stimulus velocity. The results are inconclusive regarding the velocity which evokes the highest intensity of hemodynamic response.

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Real‐Time Cerebral Hemodynamic Response to Tactile Somatosensory Stimulation

Cited by 9 publications

References 37 publications

Most High-Intensity Transient Signals Are Not Associated With Specific Surgical Maneuvers

Most High-Intensity Transient Signals Are Not Associated With Specific Surgical Maneuvers

Comparing Taste Perception Across Modalities in Healthy Adults: Liquids Versus Dissolvable Taste Strips

Classification of Tactile and Motor Velocity-Evoked Hemodynamic Response in Primary Somatosensory and Motor Cortices as Measured by Functional Near-Infrared Spectroscopy

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