Real-Time Continuous Glucose Monitoring in Adolescents and Young Adults With Type 2 Diabetes Can Improve Quality of Life

Chesser, Hannah; Srinivasan, Shylaja; Puckett, Cassidy; Gitelman, Stephen E.; Wong, Jenise C.

doi:10.1177/19322968221139873

Cited by 13 publications

(11 citation statements)

References 57 publications

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“…We demonstrate in this pilot that CGM wear in youth with T2D is feasible and effective. Similar to a recent report, 3 participants in our pilot study also expressed high satisfaction with the CGM device. In our cohort, however, we identified an improvement in HbA1c after 3 months of CGM wear, despite comparable mean HbA1c.…”

supporting

confidence: 91%

Continuous Glucose Monitoring versus Standard of Care in Adolescents With Type 2 Diabetes: A Pilot Randomized Cross-Over Trial

Chang,

Barber,

Llovido Alula

et al. 2023

J Diabetes Sci Technol

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supporting

confidence: 91%

Continuous Glucose Monitoring versus Standard of Care in Adolescents With Type 2 Diabetes: A Pilot Randomized Cross-Over Trial

Chang,

Barber,

Llovido Alula

et al. 2023

J Diabetes Sci Technol

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“…To our knowledge, only 1 other study has elicited perspectives about CGM use among AYAs with T2DM; this study assessed changes in quality of life and acceptability in AYAs who completed a 12-week period of real-time CGM use. 11 AYAs reported improved quality of life (n = 7 evaluated) and general convenience and acceptability of CGM use (1 focus group of 5 AYAs). However, studies of adolescents with type 1 diabetes have shown that perceptions of CGM use may be divided.…”

Section: Discussionmentioning

confidence: 99%

“…9 For youth with T2DM, CGM could serve to minimize the burden of frequent blood glucose monitoring, which may ultimately facilitate modifications to medication or health behaviors via improved glycemic awareness. Evidence related to clinical benefits for youth with T2DM has been limited 10 but is now emerging, 11 following trends in adult T2DM care. 12 A first step toward planning for widespread uptake of CGM among youth with T2DM is understanding patient perspectives.…”

mentioning

confidence: 99%

“…To date, attitudes about CGM by youth with T2DM have been explored in only 1 study with 5 participants. 11 This is a particularly important knowledge gap given the stark racial/ethnic disparities in diabetes technology use in youth and young adults with type 1 diabetes 13,14 and the disproportionate prevalence of T2DM among racial/ethnic minoritized youth. 15 Thus, the objective of this qualitative study was to elicit perspectives from a racially diverse group of adolescents and young adults with T2DM about CGM for T2DM management and support of healthy lifestyle.…”

mentioning

confidence: 99%

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Barriers and Facilitators to Uptake of Continuous Glucose Monitoring for Management of Type 2 Diabetes Mellitus in Youth

Peyyety,

Zupa,

Hewitt

et al. 2023

The Science of Diabetes Self-Management and Care

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Purpose: The purpose of this study was to identify factors impacting the acceptability of continuous glucose monitoring (CGM) in adolescents and young adults (AYAs) with type 2 diabetes mellitus (T2DM). Methods: In this single-center study, semistructured interviews were conducted with AYAs with T2DM and their parents to determine attitudes about CGM, including barriers and facilitators. Interviews were audio-recorded, transcribed, and evaluated using thematic analysis. Results: Twenty AYAs and 10 parents participated (n = 30 total). AYAs were mean age 16.5 years (SD 2.2, range = 13.7-20.1) and had median diabetes duration of 1.3 years. Most were female (65%) and from minoritized background (40% non-Hispanic Black, 10% Hispanic, 5% Asian). Seven (35%) used CGM. The primary facilitator elicited was convenience over glucose meter use. Important barriers included the impact of physically wearing the device and drawing unwanted attention, desire for AYA privacy, and inadequate education about the device. Conclusions: In this diverse sample of AYAs with T2DM and their parents, CGM was generally regarded as convenient, although concerns about worsening stigma and conflict with parents were prevalent. These findings can guide the development of patient-centered approaches to CGM for AYAs with T2DM, a critical step toward reducing inequities in diabetes technology uptake.

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“…First and foremost, all children with T2D should receive comprehensive education on self-management that includes teaching glycemic self-monitoring as long as needed and during periods of acute illness when symptoms of hyper- or hypoglycemia most often occur. Glucose monitoring or possibly even interstitial glucose sensor monitoring becomes imperative in patients on insulin therapy [ 85 ]. Just as for patients with T1D, HbA1c should be periodically monitored [ 79 ].…”

Section: Treatmentmentioning

confidence: 99%

From Metabolic Syndrome to Type 2 Diabetes in Youth

et al. 2023

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In the frame of metabolic syndrome, type 2 diabetes emerges along a continuum of the risk from the clustering of all its components, namely visceral obesity, high blood pressure and lipids, and impaired glucose homeostasis. Insulin resistance is the hallmark common to all the components and, in theory, is a reversible condition. Nevertheless, the load that this condition can exert on the β-cell function at the pubertal transition is such as to determine its rapid and irreversible deterioration leading to plain diabetes. The aim of this review is to highlight, in the context of metabolic syndrome, age-specific risk factors that lead to type 2 diabetes onset in youth; resume age specific screening and diagnostic criteria; and anticipate potential for treatment. Visceral obesity and altered lipid metabolism are robust grounds for the development of the disease. Genetic differences in susceptibility to hampered β-cell function in the setting of obesity and insulin resistance largely explain why some adolescents with obesity do develop diabetes at a young age and some others do not. Lifestyle intervention with a healthy diet and physical activity remains the pillar of the type 2 diabetes treatment in youth. As to the pharmacological management, metformin and insulin have failed to rescue β-cell function and to ensure long-lasting glycemic control in youth. A new era might start with the approval for use in pediatric age of drugs largely prescribed in adults, such as dipeptidyl peptidase-4 and sodium-dependent glucose transport inhibitors, and of new weight-lowering drugs in the pipeline such as single and multiple agonists of the glucagon-like peptide 1 receptor. The latter drugs can have tremendous impact on the natural history of the disease. By treating diabetes, they will reduce the burden of all the metabolic abnormalities belonging to the syndrome while causing a tremendous weight loss hitherto never seen before.

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Real-Time Continuous Glucose Monitoring in Adolescents and Young Adults With Type 2 Diabetes Can Improve Quality of Life

Cited by 13 publications

References 57 publications

Continuous Glucose Monitoring versus Standard of Care in Adolescents With Type 2 Diabetes: A Pilot Randomized Cross-Over Trial

Continuous Glucose Monitoring versus Standard of Care in Adolescents With Type 2 Diabetes: A Pilot Randomized Cross-Over Trial

Barriers and Facilitators to Uptake of Continuous Glucose Monitoring for Management of Type 2 Diabetes Mellitus in Youth

From Metabolic Syndrome to Type 2 Diabetes in Youth

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