Real-time continuous measurement of intraoperative trace exhaled propofol by planar differential mobility spectrometry

Abstract

In order to study the anesthetic pharmacokinetics and adequately adjust the anaesthesia depth of patients, real-time measurement of intraoperative exhaled propofol concentration is of significant importance for anaesthetists. Although a...

Exhaled breath is found to be better than blood samples for determining propofol concentrations in the brain tissues of rats

“…[1] In the last two decades, different mass spectrometers have been developed to achieve the goal of on-line propofol monitoring, such as proton transfer reaction mass spectrometry, [2,3] selected ion flow tube mass spectrometry [4] and ion molecule reaction mass spectrometry (IMR-MS) [5]. However, these instruments still have disadvantages such as loud noise and large volume [6]. Although devices based on ion mobility spectrometry (IMS) are small in size [7,8], such as Edmon, a product based on multi-capillary column-IMS (MCC-IMS) launched in 2017, its sensitivity can be easily affected by moisture [9].…”