Real-time, contrast enhanced photoacoustic imaging of cancer in a mouse window chamber

Olafsson, Ragnar; Bauer, Daniel R.; Montilla, Leonardo G.; Witte, Russell S.

doi:10.1364/oe.18.018625

Cited by 48 publications

(31 citation statements)

References 16 publications

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“…Several research groups have conducted photoacoustic imaging of prostate cancer in vivo using animal models (76)(77)(78)(79)(80) ) was performed in 0.2-mm increments on three metastatic and nine benign lymph nodes excised from eight melanoma patients undergoing lymphadenectomy by using a 21-MHz linear US array (Vevo LAZR, Fujifilm VisualSonics) at 20-minute scans for each node (98). Results indicate that metastasized melanin was differentially detected from blood in resected human lymph nodes.…”

Section: Prostate Cancermentioning

confidence: 99%

Photoacoustic Imaging in Oncology: Translational Preclinical and Early Clinical Experience

Valluru¹,

Wilson²,

Willmann³

2016

Radiology

166

107

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Section: Prostate Cancermentioning

confidence: 99%

Photoacoustic Imaging in Oncology: Translational Preclinical and Early Clinical Experience

Valluru¹,

Wilson²,

Willmann³

2016

Radiology

166

107

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“…In addition, the array-based imaging systems have the potential to be integrated with ultrasound imaging systems, and indeed many of the arrays in use in photoacoustic systems are taken from ultrasound systems. [2][3][4] In this paper we consider a linear transducer array that is similar to the ones used in current photoacoustic and ultrasound imaging systems.…”

Section: Introductionmentioning

confidence: 99%

Comparison of photoacoustic image reconstruction algorithms using the channelized Hotelling observer

Petschke

Rivière

2013

J. Biomed. Opt

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Abstract. We demonstrate the use of task-based image-quality metrics to compare various photoacoustic imagereconstruction algorithms, including a method based on the pseudoinverse of the system matrix, simple backprojection, filtered backprojection, and a method based on the Fourier transform. We use a three-dimensional forward model with a linear transducer array to simulate a photoacoustic imaging system. The reconstructed images correspond with two-dimensional slices of the object and are 128 × 128 pixels. In order to compare the algorithms, we use channelized Hotelling observers that predict the detection ability of human observers. We use two sets of channels: constant Q and difference of Gaussian spatial frequency channels. We look at three tasks, identification of a point source in a uniform background, identification of a 0.5-mm cube in a uniform background, and identification of a point source in a lumpy background. For the lumpy background task, which is the most realistic of the tasks, the method based on the pseudoinverse performs best according to both sets of channels. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…19,20 Furthermore, the multimodality imaging approach has great promise due to different imaging modalities providing complementary information. [20][21][22][23] The ideal approach to theragnosis should be noninvasive and allow real-time monitoring. There are various existing technologies.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic/ultrasound dual-modality contrast agent and its application to thermotherapy

et al. 2012

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Abstract. This study investigates a photoacoustic/ultrasound dual-modality contrast agent, including extending its applications from image-contrast enhancement to combined diagnosis and therapy with site-specific targeting. The contrast agent comprises albumin-shelled microbubbles with encapsulated gold nanorods (AuMBs). The gas-filled microbubbles, whose diameters range from submicrometer to several micrometers, are not only echogenic but also can serve as drug-delivery vehicles. The gold nanorods are used to enhance the generation of both photoacoustic and photothermal signals. The optical absorption peak of the gold nanorods is tuned to 760 nm and is invariant after microbubble encapsulation. Dual-modality contrast enhancement is first described here, and the applications to cellular targeting and laser-induced thermotherapy in a phantom are demonstrated. Photoacoustic imaging can be used to monitor temperature increases during the treatment. The targeting capability of AuMBs was verified, and the temperature increased by 26°C for a laser power of 980 mW, demonstrating the potential of combined diagnosis and therapy with the dual-modality agent. Targeted photo-or acoustic-mediated delivery is also possible.

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Real-time, contrast enhanced photoacoustic imaging of cancer in a mouse window chamber

Cited by 48 publications

References 16 publications

Photoacoustic Imaging in Oncology: Translational Preclinical and Early Clinical Experience

Photoacoustic Imaging in Oncology: Translational Preclinical and Early Clinical Experience

Comparison of photoacoustic image reconstruction algorithms using the channelized Hotelling observer

Photoacoustic/ultrasound dual-modality contrast agent and its application to thermotherapy

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