Real time contrast enhanced ultrasonography in detection of liver metastases from gastrointestinal cancer

Piscaglia, Fabio; Corradi, Francesco; Mancini, Milena; Giangregorio, F.; Tamberi, Stefano; Ugolini, Giampaolo; Cola, Bruno; Bazzocchi, Alberto; Righini, R.; Pini, Paolo; Fornari, Fabio; Bolondi, Luigi

doi:10.1186/1471-2407-7-171

Cited by 72 publications

(41 citation statements)

References 39 publications

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“…In terms of vascularity, metastases can be hypovascular (in gastric, colonic, pancreatic or ovarian adenocarcinomas) with hypoechoic pattern during arterial phase, and similar during portal venous and late phases, respectively hypervascular (neuroendocrine tumors, malignant melanoma, sarcomas, renal, breast or thyroid tumors) with hyperechoic appearance during arterial phase, with washout during the portal venous phase and hypoechoic pattern 30 seconds after injection (Larsen, 2010). Using CEUS examination to detect metastases a sensitivity of 80-95% is obtained, similar to that of contrast CT and MRI (Quaia et al, 2006 ;Piscaglia et al, 2007). Intraoperative use of the procedure increases its performance even if it does not have a decisive contribution to change the therapeutic behavior (Konopke et al, 2005).…”

Section: Liver Metastasesmentioning

confidence: 70%

Ultrasound Imaging of Liver Tumors – Current Clinical Applications

Badea¹,

Ioaniţescu²

2012

Liver Tumors

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Section: Liver Metastasesmentioning

confidence: 70%

Ultrasound Imaging of Liver Tumors – Current Clinical Applications

Badea¹,

Ioaniţescu²

2012

Liver Tumors

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“…In many institutions, the ultrasound examination is performed by a radiologist, who judges the presence of metastases and other focal findings during dynamic visualization of the liver, usually not following a thoroughly standardized scanning protocol [19]. We have seen an advantage when examining in a standardized way, as it is possible to compare the examination before and after contrast injection in identical views.…”

Section: Discussionmentioning

confidence: 99%

Visualization of liver lesions in standardized video-documented ultrasonography – inter-observer agreement and effect of contrast injection

et al. 2015

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The aim of this study was to evaluate the inter-observer agreement and effect of contrast injection on the visibility of liver lesions by radiologists reviewing ultrasound examinations acquired by a radiographer using a standardized examination protocol. Material and method: A retrospective review was conducted by two radiologists, independently of each other, of 115 ultrasound examinations of the liver with standardized examination protocols between January 2008 and December 2012. All patients included in the study had undergone surgery for colorectal cancer. Patients attending the two-year follow-up were included. Results: Focal findings, the most common of which were cysts, were seen in 42-43 out of the 115 patients before intravenous contrast and in 46-47 patients after intravenous contrast (p=0.012). The inter-observer agreement for focal findings was 86.1% before contrast, and 90.4% after contrast (n.s.), and the corresponding kappa values were 0.72 and 0.84, respectively. Conclusion: A good inter-observer agreement between two radiologists reviewing ultrasound examinations (standardized ultrasound cine-loop method acquired by a radiographer) after surgery for colorectal cancer was obtained. Injection of contrast medium increased the visibility of liver lesions.

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“…Contrast-enhanced sonography (CEUS) has been shown to be a suitable technique for the detection of liver metastases and to be more accurate compared with conventional B-mode [3][4][5][6][7]. However, liver metastases from carcinoid tumor still represent a challenge to imaging methods because they are often small and hyperechoic, thus mimicking hemangiomas.…”

Section: Introductionmentioning

confidence: 98%

Detection of Hepatic Metastases from Carcinoid Tumor: Prospective Evaluation of Contrast-Enhanced Ultrasonography

et al. 2008

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The purpose of our study was to prospectively compare unenhanced ultrasonography (US) to contrast-enhanced US (CEUS) in the detection of hepatic metastases from carcinoid tumor. Thirty patients with carcinoid tumor prospectively underwent US, CEUS, and magnetic resonance imaging (MRI). Differences in sensitivity at US and CEUS were compared using a combination of the results of MR imaging, fine-needle biopsy, and follow-up imaging. Lesion conspicuity was assessed subjectively for US and CEUS. Seventeen patients had a total of 69 hepatic metastases. The addition of CEUS improved the detection of individual metastases from 47 (Se 68%; 95% CI: 57.0, 79.0) to 68 (Se 99%; 99% CI: 96.7, 100.0). Contrast enhancement improved the subjective conspicuity of metastases in 85% of patients. CEUS showed one more metastasis than did MRI in one patient, and MRI showed one more than did CEUS in one patient. CEUS is more sensitive than US in the detection of carcinoid liver metastases.

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Real time contrast enhanced ultrasonography in detection of liver metastases from gastrointestinal cancer

Cited by 72 publications

References 39 publications

Ultrasound Imaging of Liver Tumors – Current Clinical Applications

Ultrasound Imaging of Liver Tumors – Current Clinical Applications

Visualization of liver lesions in standardized video-documented ultrasonography – inter-observer agreement and effect of contrast injection

Detection of Hepatic Metastases from Carcinoid Tumor: Prospective Evaluation of Contrast-Enhanced Ultrasonography

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