Real-Time Control of Neutrophil Metabolism by Very Weak Ultra-Low Frequency Pulsed Magnetic Fields

Rosenspire, Allen J.; Kindzelskii, Andrei L.; Simon, Bruce J.; Petty, Howard R.

doi:10.1529/biophysj.104.056663

Cited by 36 publications

(35 citation statements)

References 49 publications

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“…Interestingly, neither exposure to the MS at 15 Hz, nor exercise itself (Ex group) had a similar effect. This result supports previous data [Wieraszko, 2000;Ahmed and Wieraszko, 2006] demonstrating the importance of MS parameters in achieving effective treatment [Shupak et al, 2004;Cook et al, 2004;Rosenspire et al, 2005]. The negative effects of MS applied at 15 Hz (15 Hz þ Ex) support this conclusion and indicate that this higher frequency may have further damaged or even destroyed the neuronal circuits.…”

Section: Discussionsupporting

confidence: 90%

Therapeutic effects of acrobatic exercise and magnetic field exposure on functional recovery after spinal cord injury in mice

Ahmed

Mekhael

Benjamin

et al. 2010

Bioelectromagnetics

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The effects of acrobatic exercise and magnetic stimulation (MS) in mice applied either separately or in combination while on recovery after spinal cord injury have been investigated. This progress has been compared in six groups of animals. The first two groups consisted of non-injured and injured animals, respectively, which were not exposed to any treatment. The third group included injured animals that participated in an acrobatic exercise and were exposed to MS applied at the frequency of 1 Hz. The animals in the fourth group were exposed to the MS (1 Hz) only, without performing any acrobatic exercises. While the mice in the fifth group participated in the acrobatic exercise and were exposed to MS at 15 Hz, the animals in group six received an acrobatic exercise without exposure to MS. The effects of the treatment were evaluated with the Basso Mouse Scale, the Horizontal Ladder Scale, and the Abnormal Posture Scale. While all groups showed improvement at the end of the study period, the animals that received exercise combined with 1 Hz MS demonstrated the best functional improvement. The animals exposed to the MS applied at a frequency of 15 Hz combined with acrobatic exercise, and those animals that were engaged in exercise and were not exposed to the MS, performed the worst. The area of the spared white matter at the lesion center correlated well with functional recovery and was greatest in the animals that received MS (1 Hz) combined with exercise.

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Section: Discussionsupporting

confidence: 90%

Therapeutic effects of acrobatic exercise and magnetic field exposure on functional recovery after spinal cord injury in mice

Ahmed

Mekhael

Benjamin

et al. 2010

Bioelectromagnetics

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“…Perhaps the high frequency transients generated at switching produce EFs that penetrate cell membranes and somehow stimulate growth. The induced EFs from pulsed magnetic fields appear to affect metabolic oscillations in neutrophils at astonishingly low magnitudes (10 À4 mV/mm) (Rosenspire et al, 2005). If this were the mechanism of interaction of applied EFs in the mammalian spinal cord, a very different protocol would be called for to maximize the response.…”

Section: Discussionmentioning

confidence: 99%

Electric field effects on human spinal injury: Is there a basis in the in vitro studies?

Robinson

Cormie

2007

Developmental Neurobiology

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An important basis for the clinical application of small DC electric current to mammalian spinal injury is the responses of neurons in culture to applied electric fields. Our recent finding that zebrafish neurons were unresponsive to applied fields prompted us to critically examine previous results. We conclude that compelling evidence for neuronal guidance and directional stimulation of growth toward either the cathode or anode in an electric field exists only for cultured Xenopus neurons, and not for any mammalian neurons. No basis for the reported success in treating spinal injury exists in the in vitro studies, and considerable research will be required if the conditions of field application in mammalian spinal injury are to be optimized.

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“…In adherent and motile neutrophils, NAD(P)H concentration, flavoprotein redox potential, and production of ROS and nitric oxide, are all periodic and exhibit defined phase relationships to an underlying metabolic oscillation; these cells exhibit non-linear substrate-level control of ROS and nitric oxide [21].…”

Section: Discussionmentioning

confidence: 99%

Exploring Leukocyte Mitochondrial Membrane Potential in Type 1 Diabetes Families

Matteucci

Ghimenti

Consani

et al. 2010

Cell Biochem Biophys

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Proper cellular function requires the maintenance of mitochondrial membrane potential (MMP) sustained by the electron transport chain. Mitochondrial dysfunction is believed to play a role in the development of diabetes and diabetic complications possibly because of the active generation of free radicals. Since MMP can be investigated in clinical settings using fluorescent probes and living whole blood cells, mitochondrial membrane alterations have been observed in some chronic disorders. We have used the mitochondrial indicator 5,5',6,6'-tetra chloro-1,1',3,3'-tetraethylbenzimidazolyl-carbocyanine iodide (JC-1) in conjunction with flow cytometry to measure the MMP in peripheral blood granulocytes from type 1 diabetes (T1D) families. The intracellular ROS levels and the respiratory burst activity were also measured. Leukocyte MMP was elevated in 20 T1D patients and their 20 non-diabetic siblings compared with 25 healthy subjects without family history of T1D. Fasting plasma glucose was the only correlate of MMP. If confirmed by further observations, the functional implications of mitochondrial hyperpolarisation (probably different among different cells) will require extensive investigation.

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Real-Time Control of Neutrophil Metabolism by Very Weak Ultra-Low Frequency Pulsed Magnetic Fields

Cited by 36 publications

References 49 publications

Therapeutic effects of acrobatic exercise and magnetic field exposure on functional recovery after spinal cord injury in mice

Therapeutic effects of acrobatic exercise and magnetic field exposure on functional recovery after spinal cord injury in mice

Electric field effects on human spinal injury: Is there a basis in the in vitro studies?

Exploring Leukocyte Mitochondrial Membrane Potential in Type 1 Diabetes Families

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