We present a quantum theory of cooling of a mechanical resonator using back-action with constant electron current. The resonator device is based on a doubly clamped nanotube, which mechanically vibrates and acts as a double quantum dot for electron transport. Mechanical vibrations and electrons are coupled electrostatically using an external gate. The fundamental eigenmode is cooled by absorbing phonons when electrons tunnel through the double quantum dot. We identify the regimes in which ground state cooling can be achieved for realistic experimental parameters.Cooling mechanical resonators has recently attracted considerable interest, as it allows ultrasensitive detection of mass [1,2,3,4], of mechanical displacements [5], and of spin [6]. An appealing prospect is to cool the mechanical resonator to its phononic ground state. This achievement would open the possibility to create and manipulate non classical states at the macroscopic scale and to study the transition from the classical to the quantum regime [7,8,9].The lowest phononic occupation number achieved so far has been experimentally realized by cooling down the resonator in a dilution fridge [10]. Another promising approach is to employ back-action, which consists of coupling mechanical oscillations to visible or microwave photons [11,12,13,14,15,16,17,18,19]. Recently, it has been theoretically proposed [20,21,22] and experimentally demonstrated [10] that back-action cooling can be achieved by coupling mechanical resonators to the constant electron current through electronic nano-devices, such as normal-metal and superconducting single-electron transistors. This approach is appealing because it is easy to implement in a dilution fridge as compared to techniques based on photons. Within this approach, however, modest occupations of the phononic ground state have been predicted [19,20,21,22]. In particular, using an analogy with laser cooling of atoms [23], back-action cooling by constant electron current in these systems is essentially analogous to Doppler cooling [21].In this Letter, we theoretically demonstrate ground state cooling of a mechanical nanotube resonator using constant electron current. Specifically, the nanotube is employed both as the mechanical resonator and the electronic device through which the current flows. In addition, we consider the device layout in which the nanotube acts as a double quantum dot (DQD). This setup allows us to access an analogous regime of sideband cooling of the oscillator [23]. Calculations are carried out by including the coupling of the resonator to the thermal noise of the electrodes and the effect of electronic dephasing inside the DQD. For realistic device parameters the temperature is lowered by a factor of about 100. Moreover, we identify the regime in which the oscillator ground state can reach more than 90% occupation.The device layout is sketched in Fig. 1(a). The DQD system is obtained by locally depleting a semiconducting nanotube with gate T [24,25,26,27]. The dot on the right is suspended, so it...