Real-Time Imaging of Immune Modulation by Cannabinoids Using Intravital Fluorescence Microscopy

Kamali, Kiyana; Lafreniere, J Daniel; Lehmann, Christian

doi:10.1089/can.2020.0179

Cited by 2 publications

(1 citation statement)

References 70 publications

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“…For this technique, fluorescent cells, contrast agents, or autofluorescence are utilized [245]. A conventional fluorescent microscope exploits only one photon to excite a fluorophore, whereas a multiphoton microscopy excites fluorophores with multiple photons [246]. As such, it is important to consider the appropriate modality to reach sufficient depth to image cells and tissues of interest [247].…”

Section: Optical Imagingmentioning

confidence: 99%

Preclinical Models for Cryptococcosis of the CNS and Their Characterization Using In Vivo Imaging Techniques

Roosen,

Maes,

Musetta

et al. 2024

JoF

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Infections caused by Cryptococcus neoformans and Cryptococcus gattii remain a challenge to our healthcare systems as they are still difficult to treat. In order to improve treatment success, in particular for infections that have disseminated to the central nervous system, a better understanding of the disease is needed, addressing questions like how it evolves from a pulmonary to a brain disease and how novel treatment approaches can be developed and validated. This requires not only clinical research and research on the microorganisms in a laboratory environment but also preclinical models in order to study cryptococci in the host. We provide an overview of available preclinical models, with particular emphasis on models of cryptococcosis in rodents. In order to further improve the characterization of rodent models, in particular the dynamic aspects of disease manifestation, development, and ultimate treatment, preclinical in vivo imaging methods are increasingly used, mainly in research for oncological, neurological, and cardiac diseases. In vivo imaging applications for fungal infections are rather sparse. A second aspect of this review is how research on models of cryptococcosis can benefit from in vivo imaging methods that not only provide information on morphology and tissue structure but also on function, metabolism, and cellular properties in a non-invasive way.

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Section: Optical Imagingmentioning

confidence: 99%

Preclinical Models for Cryptococcosis of the CNS and Their Characterization Using In Vivo Imaging Techniques

Roosen,

Maes,

Musetta

et al. 2024

JoF

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Cannabinoid effects in the microvasculature – CB, or not CB? That is the question! A mini-review

Lehmann

2023

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Cannabinoids play critical roles in human pathophysiology through the cannabinoid (CB) receptors and non-CB receptors on variety of cells, tissues, and organs. Microvasculature with the inside bloodstream containing the plasmatic and cellular components exerts multiple functions in maintaining tissue and organ physiology through microcirculation. This review focusses on the impact of cannabinoids on the microvasculature, including mechanisms mediated by both CB receptor-related pathways and CB receptor-independent pathways.

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Real-Time Imaging of Immune Modulation by Cannabinoids Using Intravital Fluorescence Microscopy

Cited by 2 publications

References 70 publications

Preclinical Models for Cryptococcosis of the CNS and Their Characterization Using In Vivo Imaging Techniques

Preclinical Models for Cryptococcosis of the CNS and Their Characterization Using In Vivo Imaging Techniques

Cannabinoid effects in the microvasculature – CB, or not CB? That is the question! A mini-review

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