Real time in vitro monitoring and impedance modeling of mammalian cell activities on planar ECIS and micro/nano patterned cytosensors

Mondal, Debasis; RoyChaudhuri, C.

doi:10.1007/s41683-018-0024-4

Cited by 5 publications

(1 citation statement)

References 72 publications

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“…It is an in vitro method that allows analysis of cell activity based on cell structure, morphology, ability to reproduce, divide or move. The wide measurement capabilities have allowed the development of many technical upgrades of this method depending on different applications [ 11 , 12 , 13 ]. Currently, it is used, among others to determine the invasive nature of cancer cells, substance toxicity, or drug testing.…”

Section: Methodsmentioning

confidence: 99%

Electric cell-substrate impedance sensing in biocompatibility research

Kociubiński

2021

Journal of Electrical Bioimpedance

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In this paper, the possibility of using cell culture impedance measurements to assess the biocompatibility of a material in contact with cells was analyzed. For this purpose, the Electric Cell-substrate Impedance Sensing (ECIS) method and a commercial measuring device were used. The test substrates with thin-film electrodes made of various metals were prepared using the magnetron sputtering method. The choice of metals was dictated by their varying degrees of biocompatibility. Cultures of mouse fibroblasts were cultured on the prepared substrates. The experiment showed that the complete cycle of culture from attachment and reproduction to apoptosis occurred. The results obtained indicate that it is possible to use the ECIS method to study the influence of metal on cell culture activity.

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Section: Methodsmentioning

confidence: 99%