Real-time monitoring of calcium carbonate and cationic peptide deposition on carboxylate-SAM using a microfluidic SAW biosensor

Pohl, Anna; Weiss, Ingrid M.

doi:10.3762/bjnano.5.193

Cited by 13 publications

(10 citation statements)

References 48 publications

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“…Chitin synthase Ar-CS1 ( Atrina rigida ) was studied in more detail [12,13,14]. As a biomineralization transmembrane protein, the different domains might interact with the organic (chitin) and mineral (CaCO 3 ) phase as well as with other factors relevant for regulation, like pH, ion concentration, or mechanical properties of the mineral.…”

Section: Resultsmentioning

confidence: 99%

“…Two thoroughly studied examples of proteins involved in biomineralization from mollusks are chitin synthase as a protein involved in regulation and formation of chitin and the second example, perlucin as a matrix protein. Chitin synthase Ar-CS1 ( Atrina rigida ) was studied in more detail [ 12 , 13 , 14 ]. As a biomineralization transmembrane protein, the different domains might interact with the organic (chitin) and mineral (CaCO 3 ) phase as well as with other factors relevant for regulation, like pH, ion concentration, or mechanical properties of the mineral.…”

Section: Resultsmentioning

confidence: 99%

“…Precise mechanisms, binding constants, as well as morphologies of mineral deposits are difficult to analyze. Possible approaches for biomineralization proteins/peptides include potentiometric titration assay [ 17 ], biosensors [ 14 ], and electron microscopy of crystallites [ 21 ]. Hypothetic models include attraction and repulsion, with spatial arranged charge carriers of the inorganic phase, considering the different length scales of charge distances of peptides and minerals.…”

Section: Discussionmentioning

confidence: 99%

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Biogenic and Synthetic Peptides with Oppositely Charged Amino Acids as Binding Sites for Mineralization

et al. 2017

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Proteins regulate diverse biological processes by the specific interaction with, e.g., nucleic acids, proteins and inorganic molecules. The generation of inorganic hybrid materials, such as shell formation in mollusks, is a protein-controlled mineralization process. Moreover, inorganic-binding peptides are attractive for the bioinspired mineralization of non-natural inorganic functional materials for technical applications. However, it is still challenging to identify mineral-binding peptide motifs from biological systems as well as for technical systems. Here, three complementary approaches were combined to analyze protein motifs consisting of alternating positively and negatively charged amino acids: (i) the screening of natural biomineralization proteins; (ii) the selection of inorganic-binding peptides derived from phage display; and (iii) the mineralization of tobacco mosaic virus (TMV)-based templates. A respective peptide motif displayed on the TMV surface had a major impact on the SiO2 mineralization. In addition, similar motifs were found in zinc oxide- and zirconia-binding peptides indicating a general binding feature. The comparative analysis presented here raises new questions regarding whether or not there is a common design principle based on acidic and basic amino acids for peptides interacting with minerals.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Biogenic and Synthetic Peptides with Oppositely Charged Amino Acids as Binding Sites for Mineralization

et al. 2017

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“…One type of self-assembly is template-guided self-assembly, which plays an important role in biological processes relevant for biomineralization [7][8][9][10][11][12]. There are numerous approaches to harness and use this principle for artificial processes, which may be of great technological significance [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Template-controlled mineralization: Determining film granularity and structure by surface functionality patterns

Blumenstein¹,

Berson²,

Walheim³

et al. 2016

Nano Online

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We present a promising first example towards controlling the properties of a self-assembling mineral film by means of the functionality and polarity of a substrate template. In the presented case, a zinc oxide film is deposited by chemical bath deposition on a nearly topography-free template structure composed of a pattern of two self-assembled monolayers with different chemical functionality. We demonstrate the template-modulated morphological properties of the growing film, as the surface functionality dictates the granularity of the growing film. This, in turn, is a key property influencing other film properties such as conductivity, piezoelectric activity and the mechanical properties. A very pronounced contrast is observed between areas with an underlying fluorinated, low energy template surface, showing a much more (almost two orders of magnitude) coarse-grained film with a typical agglomerate size of around 75 nm. In contrast, amino-functionalized surface areas induce the growth of a very smooth, fine-grained surface with a roughness of around 1 nm. The observed influence of the template on the resulting clear contrast in morphology of the growing film could be explained by a contrast in surface adhesion energies and surface diffusion rates of the nanoparticles, which nucleate in solution and subsequently deposit on the functionalized substrate.1763

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“…One type of self-assembly is template-guided self-assembly, which plays an important role in biological processes relevant for biomineralization [ 7 – 12 ]. There are numerous approaches to harness and use this principle for artificial processes, which may be of great technological significance [ 13 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

Template-controlled mineralization: Determining film granularity and structure by surface functionality patterns

Blumenstein¹,

Berson²,

Walheim³

et al. 2015

Beilstein J. Nanotechnol.

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SummaryWe present a promising first example towards controlling the properties of a self-assembling mineral film by means of the functionality and polarity of a substrate template. In the presented case, a zinc oxide film is deposited by chemical bath deposition on a nearly topography-free template structure composed of a pattern of two self-assembled monolayers with different chemical functionality. We demonstrate the template-modulated morphological properties of the growing film, as the surface functionality dictates the granularity of the growing film. This, in turn, is a key property influencing other film properties such as conductivity, piezoelectric activity and the mechanical properties. A very pronounced contrast is observed between areas with an underlying fluorinated, low energy template surface, showing a much more (almost two orders of magnitude) coarse-grained film with a typical agglomerate size of around 75 nm. In contrast, amino-functionalized surface areas induce the growth of a very smooth, fine-grained surface with a roughness of around 1 nm. The observed influence of the template on the resulting clear contrast in morphology of the growing film could be explained by a contrast in surface adhesion energies and surface diffusion rates of the nanoparticles, which nucleate in solution and subsequently deposit on the functionalized substrate.

show abstract

Real-time monitoring of calcium carbonate and cationic peptide deposition on carboxylate-SAM using a microfluidic SAW biosensor

Cited by 13 publications

References 48 publications

Biogenic and Synthetic Peptides with Oppositely Charged Amino Acids as Binding Sites for Mineralization

Biogenic and Synthetic Peptides with Oppositely Charged Amino Acids as Binding Sites for Mineralization

Template-controlled mineralization: Determining film granularity and structure by surface functionality patterns

Template-controlled mineralization: Determining film granularity and structure by surface functionality patterns

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