Real-Time Monitoring of High-Intensity Focused Ultrasound Treatment Using Axial Strain and Axial-Shear Strain Elastograms

Xia, Ronghui; Thittai, Arun K.

doi:10.1016/j.ultrasmedbio.2013.10.006

Cited by 16 publications

(20 citation statements)

References 53 publications

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“…Frequency domain estimation of pulse-echo time shifts has also been reported using a zero-crossing detector (94–96). Recently, axial-shear strain elastograms have been proposed as an improvement to traditional axial-strain elastograms in thermal strain imaging, especially when cavitation bubbles are present (97). Using strong reflectors in tissue (ex.…”

Section: Specific Strategies For Ultrasound Thermometry and Ablatimentioning

confidence: 99%

Thermometry and ablation monitoring with ultrasound

Lewis

Staruch

Chopra

2015

International Journal of Hyperthermia

150

102

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Section: Specific Strategies For Ultrasound Thermometry and Ablatimentioning

confidence: 99%

Thermometry and ablation monitoring with ultrasound

Lewis

Staruch

Chopra

2015

International Journal of Hyperthermia

150

102

View full text Add to dashboard Cite

“…For HIFU treatment monitoring, several elasticity imaging techniques have been developed for monitoring changes in tissue elasticity during HIFU treatment, including MRE [18], ultrasound quasi-static elastography [19][20], SSI [21]–[23], ARFI [24][25], and HMI [26][10]. MRE has been proven to be feasible for assessing HIFU-induced thermal lesions [18]; however, it has the limitations of MRI, as mentioned before.…”

Section: Introductionmentioning

confidence: 99%

Harmonic motion imaging for abdominal tumor detection and high-intensity focused ultrasound ablation monitoring: an in vivo feasibility study in a transgenic mouse model of pancreatic cancer

Chen

Hou

Han

et al. 2015

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Harmonic motion imaging (HMI) is a radiation force-based elasticity imaging technique that tracks oscillatory tissue displacements induced by sinusoidal ultrasonic radiation force to assess relative tissue stiffness. The objective of this study was to evaluate the feasibility of HMI in pancreatic tumor detection and high-intensity focused ultrasound (HIFU) treatment monitoring. The HMI system consisted of a focused ultrasound transducer, which generated sinusoidal radiation force to induce oscillatory tissue motion at 50 Hz, and a diagnostic ultrasound transducer, which detected the axial tissue displacements based on acquired radiofrequency signals using a 1D cross-correlation algorithm. For pancreatic tumor detection, HMI images were generated for pancreatic tumors in transgenic mice and normal pancreases in wild-type mice. The obtained HMI images showed a high contrast between normal and malignant pancreases with an average peak-to-peak HMI displacement ratio of 3.2. Histological analysis showed that no tissue damage was associated with HMI when it was used for the sole purpose of elasticity imaging. For pancreatic tumor ablation monitoring, the focused ultrasound transducer was operated with a higher acoustic power and longer pulse length than that used in tumor detection to simultaneously induce HIFU thermal ablation and oscillatory tissue displacements, allowing HMI monitoring without interrupting tumor ablation. HMI monitoring of HIFU ablation found significant decreases in the peak-to-peak HMI displacements before and after HIFU ablation with a reduction rate ranging from 15.8% to 57.0%. The formation of thermal lesions after HIFU exposure was confirmed by histological analysis. This study demonstrated the feasibility of HMI in abdominal tumor detection and HIFU ablation monitoring.

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“…Noninvasive echo-shift-based thermography is capable of sub-millimeter mapping of HIFU focal zone based on the tissue echo shifts induced by changes in speed of sound with temperature rise [9–11]. Other ultrasound-based techniques have also investigated the distinctive spectral characteristics from the backscattered signals of the thermal lesion [12], as well as assessment of elasticity properties with mechanical excitation using static [13], dynamic [14], or acoustic radiation force [15–17] for visualizing treatment targets and the induced thermal lesions [18–29]. …”

Section: Introductionmentioning

confidence: 99%

High-intensity focused ultrasound monitoring using harmonic motion imaging for focused ultrasound (HMIFU) under boiling or slow denaturation conditions

Hou

Marquet

Wang

et al. 2015

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Harmonic Motion Imaging for Focused Ultrasound (HMIFU) is a recently developed High-Intensity Focused Ultrasound (HIFU) treatment monitoring method that utilizes an amplitude-modulated therapeutic ultrasound beam to induce an oscillatory radiation force at the HIFU focus and estimates the focal tissue displacement to monitor the HIFU thermal treatment. In this study, the performance of HMIFU under acoustic, thermal and mechanical effects were investigated. The performance of HMIFU was assessed in ex vivo canine liver specimens (n=13) under slow denaturation or boiling regimes. Passive Cavitation Detector (PCD) was used to assess the acoustic cavitation activity while a bare-wire thermocouple was used to monitor the focal temperature change. During lesioning with slow denaturation, high quality displacements (correlation coefficient above 0.97) were observed under minimum cavitation noise, indicating tissue the initial-softening-then-stiffening property change. During HIFU with boiling, HMIFU monitored a consistent change in lesion-to-background displacement contrast (0.46±0.37) despite the presence of strong cavitation noise due to boiling during lesion formation. Therefore, HMIFU effectively monitored softening-then-stiffening during lesioning under slow denaturation, and detected lesioning under boiling with a distinct change in displacement contrast under boiling in the presence of cavitation. In conclusion, HMIFU was shown effective in HIFU monitoring and lesioning identification without being significantly affected by cavitation noise.

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Real-Time Monitoring of High-Intensity Focused Ultrasound Treatment Using Axial Strain and Axial-Shear Strain Elastograms

Cited by 16 publications

References 53 publications

Thermometry and ablation monitoring with ultrasound

Thermometry and ablation monitoring with ultrasound

Harmonic motion imaging for abdominal tumor detection and high-intensity focused ultrasound ablation monitoring: an in vivo feasibility study in a transgenic mouse model of pancreatic cancer

High-intensity focused ultrasound monitoring using harmonic motion imaging for focused ultrasound (HMIFU) under boiling or slow denaturation conditions

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