Real time monitoring of peptide delivery<i>in vitro</i>using high payload pH responsive nanogels

Farazi, Shegufta N.; Chen, Fan; Foster, Henry; Boquiren, Raelene; McAlpine, Shelli R.; Chapman, Robert

doi:10.1039/c9py01120j

Cited by 17 publications

(18 citation statements)

References 40 publications

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“…These drug delivery systems can be administered through different routes [ 133 , 134 ]. Nanogels can be formulated in order to be responsive to different stimuli, such as temperature [ 135 ], pH [ 136 ], and magnetic field [ 137 ]. For example, nanogels made of ovalbumin and dextran were produced by Maillard reaction and were successfully employed to improve curcumin bioaccessibility in the gastrointestinal tract, as was demonstrated in an in vitro-reproduced model.…”

Section: Nanotechnology As a Nutraceutical Properties Enhancement mentioning

confidence: 99%

Nanonutraceuticals: The New Frontier of Supplementary Food

et al. 2021

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In the last few decades, the combination between nanotechnology and nutraceutics has gained the attention of several research groups. Nutraceuticals are considered as active compounds, abundant in natural products, showing beneficial effects on human health. Unfortunately, the uses, and consequently the health benefits, of many nutraceutical products are limited by their unsuitable chemico-physical features. For example, many nutraceuticals are characterized by low water solubility, low stability and high susceptibility to light and oxygen, poor absorption and potential chemical modifications after their administration. Based on the potential efficacy of nutraceuticals and on their limiting features, nanotechnology could be considered a revolutionary innovation in empowering the beneficial properties of nutraceuticals on human health, thus enhancing their efficacy in several diseases. For this reason, nanotechnology could represent a new frontier in supplementary food. In this review, the most recent nanotechnological approaches are discussed, focusing on their ability to improve the bioavailability of the most common nutraceuticals, providing an overview regarding both the advantages and the possible limitations of the use of several nanodelivery systems. In fact, although the efficacy of smart nanocarriers in improving health benefits deriving from nutraceuticals has been widely demonstrated, the conflicting opinions on the mechanism of action of some nanosystems still reduce their applicability in the therapeutic field.

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Section: Nanotechnology As a Nutraceutical Properties Enhancement mentioning

confidence: 99%

Nanonutraceuticals: The New Frontier of Supplementary Food

et al. 2021

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“… 25 Additionally, the miniemulsion process is compatible with a wide variety of chemistries, allowing the use of a robust bio-orthogonal gelation process. 26 − 29 …”

Section: Introductionmentioning

confidence: 99%

“…Using a miniemulsion to prepare NGs allows to tune the diameter of the resulting colloids from nanometers to micrometers and to load large amounts of hydrophilic therapeutic agents . Additionally, the miniemulsion process is compatible with a wide variety of chemistries, allowing the use of a robust bio-orthogonal gelation process. − …”

Section: Introductionmentioning

confidence: 99%

Bio-Orthogonal Nanogels for Multiresponsive Release

et al. 2021

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Responsive nanogel systems are interesting for the drug delivery of bioactive molecules due to their high stability in aqueous media. The development of nanogels that are able to respond to biochemical cues and compatible with the encapsulation and the release of large and sensitive payloads remains challenging. Here, multistimuli-responsive nanogels were synthesized using a bio-orthogonal and reversible reaction and were designed for the selective release of encapsulated cargos in a spatiotemporally controlled manner. The nanogels were composed of a functionalized polysaccharide cross-linked with pH-responsive hydrazone linkages. The effect of the pH value of the environment on the nanogels was fully reversible, leading to a reversible control of the release of the payloads and a “stop-and-go” release profile. In addition to the pH-sensitive nature of the hydrazone network, the dextran backbone can be degraded through enzymatic cleavage. Furthermore, the cross-linkers were designed to be responsive to oxidoreductive cues. Disulfide groups, responsive to reducing environments, and thioketal groups, responsive to oxidative environments, were integrated into the nanogel network. The release of model payloads was investigated in response to changes in the pH value of the environment or to the presence of reducing or oxidizing agents.

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“…1a, the dual bands of an individual uorophore can generally be divided into small (normal) and large (abnormal) Stokes-shied emissions. [11][12][13] The overlap of the normal short-wavelength emission with the lowest-lying absorption band originates from the initial emissive state near the Franck-Condon excited state, while the red-shied emission far from the absorption band arises from the structurally transformed emissive state formed by additional excited-state transformations, such as enhanced charge transfer, [14][15][16][17][18][19] energy transfer, [20][21][22][23][24][25] complex formation, [26][27][28][29][30][31] and structural and/or conformational changes. Due to the signicant congurational and/or structural changes in the excited state, the ratio of short-and long-wavelength bands can be manipulated in a controllable and dynamic manner, activating unprecedented multi-colour luminescence.…”

Section: Introductionmentioning

confidence: 99%

“…Due to the signicant congurational and/or structural changes in the excited state, the ratio of short-and long-wavelength bands can be manipulated in a controllable and dynamic manner, activating unprecedented multi-colour luminescence. 9,[56][57][58][59][60][61] Regarding the specic p-conjugated structures and luminescent mechanisms, scientists have made notable achievements with intriguing systems and concepts, such as the excimer/exciplex, [26][27][28]30,31 uorescence resonance energy transfer (FRET), [20][21][22][23][24][25] twisted intramolecular charge transfer (TICT), [48][49][50][51][52][53][54][55] and excited-state intramolecular proton transfer (ESIPT). [36][37][38][39][40][41][42] Most of the mechanisms originate from the accidental discovery of a specic uorescence phenomenon, [62][63][64][65][66][67][68][69][70][71][72][73]...…”

Section: Introductionmentioning

confidence: 99%