Real-Time Monitoring of Results During First Year of Dutch Colorectal Cancer Screening Program and Optimization by Altering Fecal Immunochemical Test Cut-Off Levels

Toes‐Zoutendijk, Esther; Leerdam, Monique E. van; Dekker, Evelien; Hees, Frank van; Penning, Corine; Nagtegaal, Irıs D.; Meulen, Miriam P. van der; Vuuren, Anneke J. van; Kuipers, Ernst J.; Bonfrèr, Johannes M.G.; Biermann, Katharina; Thomeer, Maarten; Veldhuizen, Harriët van; Kroep, Sonja; Ballegooijen, Marjolein van; Meijer, Gerrit A.; Koning, Harry J. de; Spaander, Manon C.W.; Lansdorp–Vogelaar, Iris; Schipper, D.L.; Masclee, A.A.M.; Wiersma, Tjerk; Otte, J. A.; Beek, Allard J. van der; Kemenade, Folkert J. van; Stoker, Jaap; Heeten, Gerard J. den; Graaf, Eelco J. R. de; Grevenstein, Wilhelmina M U van; Kluiters, Yvette; Blankenstein, M.A.

doi:10.1053/j.gastro.2016.11.022

Cited by 188 publications

(195 citation statements)

References 26 publications

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“…The choice of the positivity cut-off, in particular with FIT, as well as the background CRC incidence and/or the self-selection of subjects at different background risk, in countries reporting a low examination coverage, may contribute to explain the residual variability in the PR and DR across the EU countries, after accounting for age, gender, screening history and screening protocol. The observed impact of increasing the positivity cut-off level in the FIT-based Dutch screening programme19 is confirming that the choice of the cut-off value for a positive screening result has a strong influence on PR, PPV and DR values.…”

Section: Discussionmentioning

confidence: 53%

Performance of colorectal cancer screening in the European Union Member States: data from the second European screening report

Senore

Basu

Anttila

et al. 2018

Gut

132

116

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ObjectiveTo present comparative data about the performance of colorectal cancer (CRC) screening programmes in the European Union Member States (EU MSs).DesignCross-sectional study. We analysed key performance indicators—participation rate, positivity rate (PR), detection rate (DR) and positive predictive value for adenomas and CRC—based on the aggregated quantitative data collected for the second EU screening report. We derived crude and pooled (through a random effects model) estimates to describe and compare trends across different MSs/regions and screening protocols.ResultsParticipation rate was higher in countries adopting faecal immunochemical test (FIT) (range: 22.8%–71.3%) than in those using guaiac faecal occult blood test (gFOBT) (range 4.5%–66.6%), and it showed a positive correlation (ρ=0.842, p<0.001) with participation in breast cancer screening in the same areas. Screening performance showed a large variability. Compliance with referral for colonoscopy (total colonoscopy (TC)) assessment ranged between 64% and 92%; TC completion rate ranged between 92% and 99%. PR and DR of advanced adenomas and CRC were higher in FIT, as compared with gFOBT programmes, and independent of the protocol among men, older subjects and those performing their first screening.ConclusionsThe variability in the results of quality indicators across population-based screening programmes highlights the importance of continuous monitoring, as well as the need to promote quality improvement efforts, as recommended in the EU guidelines. The implementation of monitoring systems, ensuring availability of data for the entire process, together with initiatives aimed to enhance reproducibility of histology and quality of endoscopy, represent a priority in screening programmes management.

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Section: Discussionmentioning

confidence: 53%

Performance of colorectal cancer screening in the European Union Member States: data from the second European screening report

Senore

Basu

Anttila

et al. 2018

Gut

132

116

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“…Nevertheless, the confirmatory colonoscopy rate in our FIT screening program, which was launched in 2004, is still unsatisfactory. Our current confirmatory colonoscopy rate (for 2016) is approximately 68%, 9 which is considerably lower than the rate in the UK and Dutch programs, 10 although it is still higher than that in other Asian countries.…”

Section: Introductionmentioning

confidence: 58%

Factors affecting compliance with confirmatory colonoscopy after a positive fecal immunochemical test in a national colorectal screening program

Cheng

Chia

et al. 2017

Cancer

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“…In the Shanghai CRC screening program, the completion rate of initial screening was high, compared with a similar screening program in Germany during 2014 (97.7% vs. 71.3%) . The main explanation is the effect of the reminder system, in which participants who did not return fecal samples on time would be reminded twice within the interval of 7 days through telephone by CHC staff.…”

Section: Discussionmentioning

confidence: 96%

The Implementation and First-Round Results of a Community-Based Colorectal Cancer Screening Program in Shanghai, China

et al. 2018

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There is good evidence of the benefits of early detection of cancer and removal of adenomas in asymptomatic individuals; however, the widespread implementation of colorectal screening programs is resource‐dependent. Such programs have been widely implemented in high‐income regions and countries in North America, Europe, Japan, and South Korea, but such programs are few in low and middle‐income countries [35]. This article describes the implementation of a comprehensive approach to colorectal cancer screening in Shanghai, China.

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Real-Time Monitoring of Results During First Year of Dutch Colorectal Cancer Screening Program and Optimization by Altering Fecal Immunochemical Test Cut-Off Levels

Abstract: Close monitoring of the implementation of the Dutch national CRC screening program allowed for instant adjustment of the FIT cut-off levels to optimize program performance.

Cited by 188 publications

References 26 publications

Performance of colorectal cancer screening in the European Union Member States: data from the second European screening report

Performance of colorectal cancer screening in the European Union Member States: data from the second European screening report

Factors affecting compliance with confirmatory colonoscopy after a positive fecal immunochemical test in a national colorectal screening program

The Implementation and First-Round Results of a Community-Based Colorectal Cancer Screening Program in Shanghai, China

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