Real-time myocardial contrast echocardiography for the detection of stress-induced myocardial ischemia

Dubart, Alain-Eric; Silva, K. G. Carvalho Da; Korosoglou, G.; Bekeredjian, Raffi; Hansen, Alexander; Hardt, Stefan E.; Rosenberg, Mark; Ferrari, Nicolas; Hoerig, Birgit; Zehelein, Joerg; Kuecherer, Helmut F.

doi:10.1007/s00392-004-0144-7

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Other clinical studies that used a continuous infusion technique include Shimoni et al (2002Shimoni et al ( ,2003; Aggeli et al (2002); Otani et al (2004), and Dubart et al (2004). Also, Miller et al (1999) and Seidel et al (2002) used an infusion technique similar to ours (Optison™ diluted in a NaCl bag); one of the authors of Miller et al (1999) was the lead author of Podell et al (1999), a paper that questioned the stability of Optison™ when added to (diluted in) normal saline.…”

Section: Contrast Agentmentioning

confidence: 93%

Vascular lesions and s-thrombomodulin concentrations from auricular arteries of rabbits infused with microbubble contrast agent and exposed to pulsed ultrasound

Zachary

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Miller

et al. 2006

Ultrasound in Medicine & Biology

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Arterial injury resulting from the interaction of contrast agent (CA) with ultrasound (US) was studied in rabbit auricular arteries and assessed by histopathologic evaluation and s-thrombomodulin concentrations. Three sites on each artery were exposed (2.8 MHz, 5-min exposure duration, 10-Hz pulse repetition frequency, 1.4-μs pulse duration) using one of three in situ peak rarefactional pressures (0.85, 3.9 or 9.5 MPa). Saline, saline/CA, and saline/US infusion groups (n = 28) did not have histopathologic damage. The saline/CA/US infusion group (n = 10) at exposure conditions below the FDA mechanical index limit of 1.9 did not have histopathologic damage, whereas the saline/CA/US infusion group (n = 9) at exposure conditions above the FDA limit did have damage (5 of 9 arteries). Lesions were characteristic of acute coagulative necrosis. Mean s-thrombomodulin concentrations, a marker for endothelial cell injury, were highest in rabbits exposed to US at 0.85 and 3.9 MPa, suggesting that vascular injury may be physiological and not accompanied by irreversible cellular injury.

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