2021
DOI: 10.1021/jacs.1c07186
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Real-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate

Abstract: Allan-Herndon-Dudley syndrome (AHDS) is characterized by neuropsychomotor developmental delay/intellectual disability, neurological impairment with a movement disorder, and an abnormal thyroid hormone profile. This disease is an X-linked disorder that mainly affects men. We described a female patient with a de novo variant in the SLC16A2 gene, a milder AHDS phenotype, and a skewed X chromosome inactivation profile. We discuss the mechanisms associated with the expression of the phenotypic characteristics in fe… Show more

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Cited by 6 publications
(6 citation statements)
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“…We caution future investigators that all solvents were used directly from the 'bench', and that we previously discovered strong water-content effects, investigating solvolysis in the BiSal 2 system. 38 Finally, using ILAG with 1-2% of NH 4 NO 3 further minimizes the amount of leover Bi 2 O 3 , and repeatably yields good results. We also implemented the heating of the jars with reaction mixture to ensure reproducibility.…”
Section: Bismuth Gallatementioning
confidence: 96%
“…We caution future investigators that all solvents were used directly from the 'bench', and that we previously discovered strong water-content effects, investigating solvolysis in the BiSal 2 system. 38 Finally, using ILAG with 1-2% of NH 4 NO 3 further minimizes the amount of leover Bi 2 O 3 , and repeatably yields good results. We also implemented the heating of the jars with reaction mixture to ensure reproducibility.…”
Section: Bismuth Gallatementioning
confidence: 96%
“…Therefore, Bi 38 is certainly a targeted node since it is more broadly related to tetravalent metal-oxo clusters (Zr/Hf/Ce/Th/U/Np/Pu IV ), , as well as topologically and compositionally similar metal oxides and viable MOF families. Intriguingly, Bi 38 was also recently described as a major species in Pepto Bismol via X-ray scattering studies.…”
Section: Introductionmentioning
confidence: 93%
“…In recent years PDF analysis has been shown to be a powerful technique for characterization of disordered materials (Christiansen et al, 2020b;Yang et al, 2013;Billinge & Kanatzidis, 2004;Keen & Goodwin, 2015), amorphous materials (Christiansen et al, 2020a;Juelsholt et al, 2021;Bennett & Cheetham, 2014), clusters in solution (Anker et al, 2021;Jensen et al, 2016;Szczerba et al, 2021) and nanomaterials (Billinge & levin, 2007;Cooper et al, 2020) where conventional crystallographic approaches are challenged (Billinge & Kanatzidis, 2004;Keen & Goodwin, 2015).…”
Section: Introductionmentioning
confidence: 99%