Real-Time PCR Assays for High-Throughput Human Platelet Antigen Typing

McBride, Simon

doi:10.1007/978-1-59745-553-4_4

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Presently, various technologies for genotyping are available (reviewed in [8,9]), including new technologies such as the real-time PCR [10] and mass-scale high-throughput multiplex PCR [11]. The great advantages of genotyping compared to antibody detection are the non-dependence on freshly isolated platelets, no reliance on antisera and the potential for automation [12].…”

Section: Platelet Antibody Detection Methods and Genotypingmentioning

confidence: 99%

The importance of platelet antigens and antibodies in immune‐mediated thrombocytopenia

Tsuno

Matsuhashi

Iino

et al. 2014

ISBT Science Series

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Platelet antigens/antibodies play an important role in immune mediated-thrombocytopenia. Here, we review the clinical conditions associated with anti-platelet alloantibodies, giving special emphasis to the differences in human platelet antigen (HPA) frequency distribution between Caucasian and Asian populations. Also, we describe the presently available methods for the detection of anti-platelet alloantibodies, and the activities of the International Society of Blood Transfusion (ISBT) Platelet Immunology Working Parties, which play an active role in the exchange of information and materials among the labs involved in platelet immunobiology research worldwide, and have significantly contributed for the development of this field.

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