Real-time sonoelastography compared to magnetic resonance imaging using four different modalities at 3.0T in the detection of prostate cancer: Strength and weaknesses

Comparison of Real-Time Elastography and Multiparametric MRI for Prostate Cancer Detection: A Whole-Mount Step-Section Analysis

“…Like those of Pelzer et al [12], our results suggest that multiparametric MRI may have advantages in the detection of transitional zone cancers. The sensitivities were 72.7% for multiparametric MRI and 18.2% for RTE (p < 0.05).…”

“…The one case of high-risk prostate cancer missed with RTE was located in the transitional zone, and the two cases missed with multiparametric MRI were not visible because of artifacts of the endorectal coil. Pelzer et al [12], who also compared RTE findings with multiparametric MRI findings for prostate cancer diagnosis, found a reduced rate of detection of low-risk prostate cancer for both methods compared with detection of high-risk prostate cancer. Slightly different from these findings, in our study population with low serum prostate-specific serum concentrations, multiparametric MRI was superior to RTE for visualization of low-risk prostate cancer (86.7% for multiparametric MRI and 57.8% for RTE; p < 0.005).…”

“…We compared diagnostic performance and estimation of tumor volume for RTE and multiparametric MRI in patients with known prostate cancer using prostate whole-mount step section as the standard of reference. To our knowledge, this is only the second study comparing RTE with multiparametric MRI and the fourth comparing RTE with MRI in general [12][13][14].…”

Impact of Real-Time Elastography on Magnetic Resonance Imaging/Ultrasound Fusion Guided Biopsy in Patients with Prior Negative Prostate Biopsies

“…The enhanced accuracy of MRI/RTE fusion could be explained by the findings of other working groups evaluating the effect of RTE to MRI. 22,23 Therefore, a higher proportion of cancers could be visualized in prostates larger than 40 cm 3 even though PCa was located in the transitional zone or anterior parts.…”

Imaging for Prostate Cancer

“…Recently, real-time sonoelastography (RTE) was compared to mpMRI where it, in several cases, performed better than the latter. However, in a recent publication both methods missed 4 out of 50 small lowgrade PC [3]. Still there are significant problems distinguishing between a benign prostate hyperplasia (BPH) nodule and PC.…”