Real-Time Tissue Differentiation Using Fiber Optic Sensing in Laser Catheters1

Beekman, Darrin; Bijadi, Sachin; Kowalewski, Timothy M.

doi:10.1115/1.4027079

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…While these kinematic models have advanced soft actuator locomotion systems, more research is needed for transcatheter clinical relevancy. Whether it is transcatheter valve replacement, atrial septal defect closure, atrial fibrillation ablation, intravascular ultrasound, excimer laser angioplasty or novel intravascular tissue sensing modalities [22], [23], most therapies or diagnostics performed intravascularly are sensitive to the degree of device contact force. Inadequate or unstable contact forces can result in sensing errors or insufficient therapy delivery [3], [4], [5], [6].…”

Section: Introductionmentioning

confidence: 99%

Force Analysis and Modelling of Soft Actuators for Catheter Robots

Gilbertson

Beekman

Mohanty

et al. 2016

Volume 2: Mechatronics; Mechatronics and Controls in Advanced Manufacturing; Modeling and Control of Automotive Systems and Com

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Soft robotic actuators may provide the means to develop a soft robotic catheter, enabling safer and more effective transcatheter procedures. In many clinical applications, device contact force affects the quality of diagnostic or the degree of therapy delivered. Therefore precise end effector force control will be a requirement for the soft robotic catheter. In this study a bending soft actuator system was fabricated, and the relationship between volume input and end effector contact force is examined. Static and dynamic system identification were conducted under two different loading conditions loosely related to actuation in a blood vessel. The experimental data from these tests led to the creation of a non-linear system model. A reduced term model was developed using a Root Mean Square Error (RMSE) method in order to observe the importance of system dynamics and nonlinearities. A different system model was designed for each loading condition. These two reduced models matched with experimental result, but differed in model terms and parameters, suggesting that either loading condition identification or end effector closed-loop sensing will be needed for accurate contact force control of a soft robotic actuator in an intravascular environment.

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Section: Introductionmentioning

confidence: 99%

Force Analysis and Modelling of Soft Actuators for Catheter Robots

Gilbertson

Beekman

Mohanty

et al. 2016

Volume 2: Mechatronics; Mechatronics and Controls in Advanced Manufacturing; Modeling and Control of Automotive Systems and Com

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Variable-Contact Diffuse Reflectance Spectroscopy in Intravascular Conditions Assessment1

Beekman

Kowalewski

2015

Journal of Medical Devices

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Background Coronary artery disease (CAD) is the number one cause of death in the U.S. [1]. 720,000 Americans are projected to undergo coronary attacks in 2014. 215,000 of these attacks are expected to be repeat episodes [2], which implies a deficiency in the current CAD percutaneous coronary interventions. Angioplasty and stenting are the most common treatment options, but these methods can trigger an injury response, swelling, and restenosis. Currently, the outcomes of alternative plaque removing treatments like excimer atherectomy or mechanical atherectomy are similar to stenting, so their use has been limited to procedures not well suited for balloon angioplasty and stenting [3]. The creation of an accurate and reliable tissue-identification sensor may enable the control of atherectomy procedures by verifying that the tissue in the ablation zone is the correct tissue to remove in between each laser pulse. A sensor with this capability would increase the safety and effectiveness of minimally invasive interventions. An optics-based sensor may be the most suited for direct application as it could utilize the optical fibers already present in the laser atherectomy catheters. Additionally, evidence suggests that fiber-optic diffuse reflectance spectroscopy (DRS) provides an accurate means of classifying tissue. The sensitivities and specificities for Stelzle et al. are generally around 90% and reach 100% for certain tissue pairs (e.g., fat and muscle) [4]. Rocha et al. provided and reviewed some of the strongest evidence that this can be used to distinguish atherosclerotic plaque and healthy tissue [5]. Accounting for contact force, however, still remains a challenge, as it can significantly alter DRS spectra [6]. Building on the prior art mentioned above and our previous investigations [7], this work aims to explore the ability of contact DRS to discriminate tissue-specific spectra under typical intravascular conditions such as variable-contact force, the inclusion of ablation effects, and immersion in blood or saline.

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Real-Time Tissue Differentiation Using Fiber Optic Sensing in Laser Catheters1

Cited by 2 publications

References 6 publications

Force Analysis and Modelling of Soft Actuators for Catheter Robots

Force Analysis and Modelling of Soft Actuators for Catheter Robots

Variable-Contact Diffuse Reflectance Spectroscopy in Intravascular Conditions Assessment1

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