Real-Time Ultrasonography for Determination of Ovarian Morphology and Volume

Campbell, Stuart; Goswamy, R. K.; Goessens, L.; Whitehead, M. I.

doi:10.1016/s0140-6736(82)91622-1

Cited by 144 publications

(55 citation statements)

References 2 publications

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“…The age, body weight and height of each patient were recorded, and a complete physical examination was performed. Ovarian volume was measured as described by Campbell et al23 Sonographic examinations using 3.5 MHz abdominal or 6.5 MHz vaginal transducers (Hitachi, EMB 450, Japan) were carried out by the same operator (N.E.) to avoid inter-observer variability.…”

Section: Methodsmentioning

confidence: 99%

Effect of thyroid hormone replacement therapy on ovarian volume and androgen hormones in patients with untreated primary hypothyroidism

Müderris

Boztosun

Öner

et al. 2011

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVES:Primary hypothyroidism may be associated with ovarian enlargement and/ or cyst formation. We evaluated the effect of thyroid hormone replacement therapy on hormonal changes, ovarian volume and sonographic appearance.DESIGN AND SETTING:Open, prospective study of women admitted to university gynecology clinic.PATIENTS AND METHODS:The study included 26 patients with untreated hypothyroidism who had polycystic (n=10) or normal-appearing (n=16) ovaries and 20 euthyroidic controls. Basal serum total testosterone, free testosterone, androstenedione, dehydroepiandosterone-sulfate, prolactin, estradiol, luteinizing hormone, follicle-stimulating hormone, free T3, free T4 and thyroid-stimulating horone, together with ovarian volumes, were determined and repeated after euthyroidism was achieved.RESULTS:Ovarian volumes of patients with hypothyroidism were significantly greater compared with controls, and their magnitudes diminished significantly during thyroid hormone replacement therapy. Hypothyroidic patients with polycystic ovaries had significantly higher serum free testosterone and dehydroepiandosterone-sulfate, but lower androstenodione levels compared with those who had normal-appearing ovaries. Serum total testosterone concentrations were significantly higher in hypothyroidic patients without polycystic ovaries, and thyroid hormone replacement therapy achieved a significant reduction in total as well as free testosterone.CONCLUSION:Severe longstanding hypothyroidism leads to increased ovarian volume and/or cyst formation. A decrease in ovarian volume, resolution of ovarian cysts and reversal of the polycystic ovary syndrome-like appearance, together with improvement in serum hormone levels, occurred after euthyroidism was achieved.

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Section: Methodsmentioning

confidence: 99%

Effect of thyroid hormone replacement therapy on ovarian volume and androgen hormones in patients with untreated primary hypothyroidism

Müderris

Boztosun

Öner

et al. 2011

Annals of Saudi Medicine

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“…The tumour volume was defined as volume calculated by the following formula: 0.524 Â largest anteroposterior dimension Â largest width dimension Â largest craniocaudal dimension (Campbell et al, 1982).…”

Section: Patient Selectionmentioning

confidence: 99%

Increased expression of pAKT is associated with radiation resistance in cervical cancer

et al. 2006

Br J Cancer

106

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Phosphorylated AKT (pAKT) is a major contributor to radioresistance in human cancers. The aim of this study was to investigate the association of pAKT expression and radiation resistance in cervical cancer. A retrospective review was made of the records of 27 women who received primary radiation therapy due to locally advanced cervical cancer (LACC) with FIGO stage IIB -IVA. Nine patients regarded as radiation resistant developed local recurrences with a median progression free interval of 9 months. Eighteen patients did not show local recurrences, and were regarded as a radiation-sensitive group. Using pretreatment paraffin-embedded tissues, we evaluated pAKT expression by immunohistochemistry. A significant association was found between the level of pAKT expression and local recurrence. Immunohistochemical staining for pAKT was significantly more frequent in the radiation-resistant than in the radiation-sensitive group (P ¼ 0.004). The mean progression-free survival was 86 months for patients with pAKT-negative staining (19 cases) and 44 months for patients with pAKT-positive expression (eight cases) (P ¼ 0.008). These results suggest that signalling from phosphatidylinositide 3-kinase/pAKT can lead to radiation resistance, and that evaluation of pAKT may be a prognostic marker for response to radiotherapy in LACC.

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“…O n thc othcr hand, because of a 1U-fold increased risk of immunization in previously transfused patients, and on account of the severe clinical consequences of Rhesus (D) Ultrasound scanning is an extremely good method of imaging the postmenopausal ovary (Campbell et al 1982) and a suitable second line screening test (cf. cervical cytology and colposcopy).…”

Section: Authors' Replymentioning

confidence: 99%