Real‐Time ultrasound of normal adrenal glands and small tumors

Günther, Rolf W.; Kelbel, C.; Lenner, V.

doi:10.1002/jcu.1870120408

Cited by 19 publications

(11 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ultrasound, however, failed to detect the majority of diffuse adrenal hyperplasia in three series with mostly adult patients [1,27,28] except in one newborn with 21-OHase deficiency and two older patients with apparently long-standing untreated disease [6,7,27]. In contrast, the patients reported here show a distinct pattern of adrenal enlargement.…”

Section: Discussioncontrasting

confidence: 72%

Age-related changes in adrenal size during the first year of life in normal newborns, infants and patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency: comparison of ultrasound and hormonal parameters

1988

View full text Add to dashboard Cite

An adrenal size index (ASI) was specifically designed to improve ultrasound evaluation of adrenal size in the 1st year of life. In 84 newborns and infants, ASI and plasma dehydroepiandrosterone sulphate (DHEA-S) concentrations were determined to study in vivo changes in adrenal size and cortical zonal composition. ASI was higher (P less than 0.0001) in the first 2 postnatal weeks (median 60.5 mm2) than in the rest of the first year (median 39.6 mm2) and showed a negative correlation with chronological age (r = -0.41). A positive correlation existed between DHEA-S concentrations and ASI (r = 0.29) as well as ASI relative to body weight (r = 0.57). These data and changes in gland echogenicity are consistent with histopathological observations that the early decrease in adrenal size is due to involution of the fetal zone. In four patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase (21-OHase) deficiency, ASI and plasma concentrations of pre-defect steroid were determined. Two patients with severe salt loss had markedly elevated ASI, which returned to normal during treatment. Two patients without severe salt loss had pretreatment ASI in the upper normal range, which decreased with treatment. Our findings indicate that ASI is useful in assessing physiological changes in adrenal size and, in conjunction with DHEA-S determinations, in adrenal cortex composition. ASI may aid in the early diagnosis of the salt-losing variety of 21-OHase deficiency. ASI is an instantaneously available tool which, in addition to biochemical and clinical data, can be used to monitor treatment of 21-OHase deficiency.

show abstract

Section: Discussioncontrasting

confidence: 72%

Age-related changes in adrenal size during the first year of life in normal newborns, infants and patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency: comparison of ultrasound and hormonal parameters

1988

View full text Add to dashboard Cite

show abstract

“…However, Yeh (7) reported that adrenal masses as small as 6mm can be detected by US. A similar report by Giinther et al (4) described that US demonstrated 12 of 13 small adrenal masses 8 to 20mm in diameter. The delineation rate by initial CT examination in this series, especially for the left APA, was superior to US.…”

Section: Discussionmentioning

confidence: 53%

“…However, the usefulness of US to detect small adrenal tumors remains controversial (1)(2)(3)(4)(5). Recently, this problem has been offset with the improvement in resolution, thereby increasing the detection rate even for small adrenal tumors (3,4,6,7). Most aldosterone-producing adenomas (APA) are too small to be detected incidentally by imaging pro cedures (8,9).…”

Section: Introductionmentioning

confidence: 99%

Ultrasonography in the Diagnosis of Aldosterone-Producing Adenoma: Is It Useful?

Yamakita

Miura

1992

Intern. Med.

View full text Add to dashboard Cite

The usefulness of ultrasonography (US) in the diagnosis of aldosterone-producing adenoma(s) (APA) was compared with computed tomography (CT) and adrenal scintigraphy in 13 patients. The initial examination with US could demonstrate four of seven right APA. Repeat examinations later in two patients whose tumors were initially not detectable did reveal a tumor in one patient. On the other hand, two left APA were delineated on the initial trial. The other seven left APA, except two small APA in one patient, could be delineated during repeat US examinations performed on other days. With CT, all APA were detected during the first or second trial except for the smallest one. The rate of localization by adrenal scintigraphy with dexamethasone pretreatment was ll of 13 patients. CT had the highest localization rate. However, US was shown to be useful in the localization diagnosis of APA on repeat examinations with a high delineation rate comparable to CT. (Internal Medicine 31: 589-592, 1992)

show abstract

“…Adrenal lesions · Unenhanced CT · Delayed enhanced CT · Chemical shift MRI · Adrenal scintigraphy · Adrenal biopsy Sonographie Die Sonographie vermag in Abhängig-keit von den Untersuchungsbedingungen und von der Erfahrung des Untersuchers Raumforderungen der Nebennieren ab einer Größe von 1 cm darzustellen [10]. Aufgrund der geringen Sensitivität (79%) und der noch geringeren Spezifität (61%) hat sich die Sonographie in der weiteren Abklä-rung von Nebennierenraumforderungen nicht durchgesetzt [10].…”

Section: Introductionunclassified

“…Aufgrund der geringen Sensitivität (79%) und der noch geringeren Spezifität (61%) hat sich die Sonographie in der weiteren Abklä-rung von Nebennierenraumforderungen nicht durchgesetzt [10].…”

Section: Introductionunclassified

Charakterisierung von Nebennierenraumforderungen

et al. 1999

View full text Add to dashboard Cite

This paper describes the diagnostic value of new imaging techniques in characterization of adrenal masses and evaluates the role of adrenal biopsy. For differentiation of benign and malignant adrenal lesions, sensitivities and specificities of 85-100% can be reached by unenhanced computed tomography (CT) methods, chemical shift techniques in magnetic resonance imaging (MRI), delayed enhanced CT techniques, and by evaluation of wash-out curves in contrast-enhanced CT. The diagnostic value of all CT techniques depends on threshold values. The value of dynamic contrast-enhanced MRI is under discussion and should be reevaluated by using delayed enhanced series. Biochemical and scintigraphic methods (NP 59 iodine iodomethyl-norcholesterol and MIBG meta-iodobenzylguanidine scintigrams) are valuable for the diagnosis of functional adrenal masses; however, they do not allow differentiation of benign and malignant tumors. According to excellent results of new imaging techniques in characterization of adrenal masses, the indications for fine-needle aspiration biopsy have already regressed, as have complications associated with this invasive technique.

show abstract

Real‐Time ultrasound of normal adrenal glands and small tumors

Cited by 19 publications

References 8 publications

Age-related changes in adrenal size during the first year of life in normal newborns, infants and patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency: comparison of ultrasound and hormonal parameters

Age-related changes in adrenal size during the first year of life in normal newborns, infants and patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency: comparison of ultrasound and hormonal parameters

Ultrasonography in the Diagnosis of Aldosterone-Producing Adenoma: Is It Useful?

Charakterisierung von Nebennierenraumforderungen

Contact Info

Product

Resources

About