Real-time visualization of high-intensity focused ultrasound treatment using ultrasound imaging

Vaezy, Shahram; Shi, Xiaotian; Martin, Roy W.; Chi, Emil; Nelson, P; Bailey, Michael R.; Crum, Lawrence A.

doi:10.1016/s0301-5629(00)00279-9

Cited by 320 publications

(187 citation statements)

References 18 publications

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“…Thirdly, realtime therapy. For whole process of therapy, it is a real-time targeting and monitoring process, real-time estimating therapeutic effect and adjusting dosage [19] . Fourthly, suitable therapy.…”

Section: Discussionmentioning

confidence: 99%

Analysis of clinical effect of high-intensity focused ultrasound on liver cancer

Li¹,

Xu²,

Jiang³

et al. 2004

WJG

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AIM:To evaluate the clinical effect of high-intensity focused ultrasound (HIFU) in the treatment of patients with liver cancer.METHODS: HIFU treatment was performed in 100 patients with liver cancer under general anesthesia and by a targeted ultrasound. Evaluation of efficacy was made on the basis of clinical symptoms, liver function tests, AFP, MRI or CT before and after the treatment. RESULTS:After HIFU treatment, clinical symptoms were relieved in 86.6%(71/82) of patients. The ascites disappeared in 6 patients. ALT (95±44) U/L and AST (114±58) U/L before HIFU treatment were reduced to normal in 83.3%(30/36) and 72.9%(35/48) patients, respectively, after the treatment. AFP was lowered by more than 50% in 65.3%(32/49) patients. After HIFU treatment, MRI or CT findings indicated coagulation necrosis and blood supply reduction or disappearance of tumor in the target region.CONCLUSION: HIFU can efficiently treat the patients with liver cancer. It will offer a significant noninvasive therapy for local treatment of liver tumor.

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Section: Discussionmentioning

confidence: 99%

Analysis of clinical effect of high-intensity focused ultrasound on liver cancer

Li¹,

Xu²,

Jiang³

et al. 2004

WJG

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“…In conventional devices of focused ultrasound therapy, magnetic resonance imaging (MRI) and ultrasonic imaging have been used for treatment monitoring. 12,13) Since the lifetime of cavitation bubbles is on the order of 1 ms and up to the order of 10 ms even under sustained oscillation for maintaining the presence of bubbles, [14][15][16] the guidance by high-speed ultrasonic imaging achieving a frame rate of more than 1 kfps using unfocused transmission is promising. [17][18][19][20] Microbubbles such as cavitation bubbles are known to oscillate nonlinearly, and harmonic imaging is widely used for their detection.…”

Section: Introductionmentioning

confidence: 99%

Selective detection of cavitation bubbles by triplet pulse sequence in high-intensity focused ultrasound treatment

Iwasaki

Nagaoka

Yoshizawa

et al. 2018

Jpn. J. Appl. Phys.

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Acoustic cavitation bubbles are known to enhance the heating effect in high-intensity focused ultrasound (HIFU) treatment. The detection of cavitation bubbles with high sensitivity and selectivity is required to predict the therapeutic and side effects of cavitation, and ensure the efficacy and safety of the treatment. A pulse inversion (PI) technique has been widely used for imaging microbubbles through enhancing the second-harmonic component of echo signals. However, it has difficulty in separating the nonlinear response of microbubbles from that due to nonlinear propagation. In this study, a triplet pulse (3P) method was investigated to specifically image cavitation bubbles by extracting the 1.5th fractional harmonic component. The proposed 3P method depicted cavitation bubbles with a contrast ratio significantly higher than those in conventional imaging methods with and without PI. The results suggest that the 3P method is effective for specifically detecting microbubbles in cavitation-enhanced HIFU treatment.

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“…We have been investigating ultrasound image-guided High Intensity Focused Ultrasound (HIFU) as a method for non-invasive hemorrhage control (Vaezy et al 2001a). HIFU therapy is capable of delivering cauterization energy deep inside the body, with millimeter accuracy, and with little or no damage to the intervening and surrounding tissues (Chen et al 1993;Vaezy et al 2001b).…”

Section: Introductionmentioning

confidence: 99%

“…Developing HIFU therapy into a non-invasive treatment modality requires precise localization and targeting of the injured sites, and monitoring of the HIFU treatment. Diagnostic ultrasound imaging (e.g., Power and Color Doppler) may be an efficient, real-time, and relatively cheap solution for both bleeding localization and HIFU treatment guidance (Vaezy et al 2001a). Although arteriography remains the gold standard, resent reports indicate the usefulness of ultrasound in localization of vascular injuries (Britt et al 2001;Davison and Polak 2004).…”

Section: Introductionmentioning

confidence: 99%

Pulsatile Flow Phantom for Ultrasound Image-Guided HIFU Treatment of Vascular Injuries

Greaby

Zderic

Vaezy

2007

Ultrasound in Medicine & Biology

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A pulsatile flow phantom was developed for studies of ultrasound image-guided High Intensity Focused Ultrasound (HIFU) application in transcutaneous hemostasis of injured blood vessels. The flow phantom consisted of a pulsatile pump system with instrumented excised porcine carotid artery, which was imbedded in a transparent agarose gel to model structural configuration of in-vivo tissues. Heparinized porcine blood was circulated through the phantom. The artery was injured using an 18 Gauge needle to model a penetrating injury in human peripheral vasculature. A HIFU transducer with the diameter of 7 cm, focal length of 6.3 cm and frequency of 3.4 MHz was used to seal the puncture. Ultrasound imaging was used to localize and target the puncture site, and monitor the HIFU treatment. Triphasic blood flows present in the human arteries were reproduced, with flow rates of 50-500 ml/min, pulse rates of 62-138 beats/min, and peak pressures of 100-250 mmHg. The penetrating injury of an artery was mimicked successfully in the flow phantom setting, and was easily visualized both optically through the transparent gel and with Power Doppler ultrasound imaging. Hemostasis was achieved in 55 ± 31 s (n=9) of HIFU application. Histological observations showed that a HIFU-sealed puncture was filled with clotted blood and covered with a fibrin cap. The pulsatile flow phantom provides a controlled and repeatable environment for studies of transcutaneous imageguided HIFU application in hemostasis of a variety of blood vessel injuries.

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Real-time visualization of high-intensity focused ultrasound treatment using ultrasound imaging

Cited by 320 publications

References 18 publications

Analysis of clinical effect of high-intensity focused ultrasound on liver cancer

Analysis of clinical effect of high-intensity focused ultrasound on liver cancer

Selective detection of cavitation bubbles by triplet pulse sequence in high-intensity focused ultrasound treatment

Pulsatile Flow Phantom for Ultrasound Image-Guided HIFU Treatment of Vascular Injuries

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