Real versus imagined locomotion: A [18F]-FDG PET-fMRI comparison

Fougère, Christian la; Zwergal, Andreas; Rominger, Axel; Förster, Stefan; Fesl, Gunther; Dieterich, Marianne; Brandt, Thomas; Strupp, Michael; Bartenstein, Peter; Jahn, Klaus

doi:10.1016/j.neuroimage.2009.12.060

Cited by 356 publications

(373 citation statements)

References 41 publications

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“…The major activated areas were the motor/premotor and multisensory cortices, parahippocampal gyri and midline cerebellum. There were deactivations in multisensory vestibular cortical areas in both conditions 28 . In MS patients, it has been shown that an ipsilateral sensorimotor cortex deactivation with a simple motor task 29 and an existence of compensatory cortical activations at the earliest stage of MS were mainly located in regions involved in executive processing 13,30 .…”

Section: Discussionmentioning

confidence: 88%

Walking execution is not affected by divided attention in patients with multiple sclerosis with no disability, but there is a motor planning impairment

Nogueira

Santos

Sabino

et al. 2013

Arq. Neuro-Psiquiatr.

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ARTICLE 521Walking execution is not affected by divided attention in patients with multiple sclerosis with no disability, but there is a motor planning impairment A execução da marcha não é afetada pela atenção dividida em pacientes com esclerose múltipla sem incapacidade, mas existe um comprometimento do planejamento motor ABSTRACT Purpose: We analysed the cognitive influence on walking in multiple sclerosis (MS) patients, in the absence of clinical disability. Method: A case-control study was conducted with 12 MS patients with no disability and 12 matched healthy controls. Subjects were referred for completion a timed walk test of 10 m and a 3D-kinematic analysis. Participants were instructed to walk at a comfortable speed in a dual-task (arithmetic task) condition, and motor planning was measured by mental chronometry. Results: Scores of walking speed and cadence showed no statistically significant differences between the groups in the three conditions. The dual-task condition showed an increase in the double support duration in both groups. Motor imagery analysis showed statistically significant differences between real and imagined walking in patients. Conclusion: MS patients with no disability did not show any influence of divided attention on walking execution. However, motor planning was overestimated as compared with real walking.Key words: mild cognitive impairment, multiple sclerosis, walking. RESUMOO objetivo do estudo foi analisar a influência cognitiva na caminhada de pacientes com esclerose múltipla (EM) sem incapacidade clínica. Foi conduzido um estudo caso-controle com 12 pacientes com EM sem incapacidade com 12 pessoas saudáveis como controles pareados. Os sujeitos fizeram um teste de caminhada de 10 metros , acompanhado de análise cinemática 3D, e foram orientados a caminhar em velocidade confortável, realizando dupla-tarefa (tarefa aritmética), e o planejamento motor foi medido pela cronometria mental. Os valores de velocidade da caminhada e da cadência não evidenciaram diferenças estatisticamente significativas entre os grupos nas três condições. A condição de dupla-tarefa demonstrou um aumento na duração do duplo apoio em ambos os grupos. A imagética motora evidenciou diferenças estatisticamente significativas entre a caminhada real e a imaginada nos pacientes com EM. Pacientes com EM sem incapacidade não apresentaram influência da atenção dividida na execução da caminhada. Entretanto, o planejamento motor esteve superestimado.Palavras-Chave: comprometimento cognitivo leve, esclerose múltipla, caminhada.

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Section: Discussionmentioning

confidence: 88%

Walking execution is not affected by divided attention in patients with multiple sclerosis with no disability, but there is a motor planning impairment

Nogueira

Santos

Sabino

et al. 2013

Arq. Neuro-Psiquiatr.

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“…Real locomotion FDG PET studies have also confirmed a prominent activation in the vermal and paravermal cerebellum, with extensions into the superior cerebellar peduncle bilaterally (Ishii, 1995;la Fougere et al, 2010).…”

Section: Discussionmentioning

confidence: 94%

Progressive gait ataxia following deep brain stimulation for essential tremor: adverse effect or lack of efficacy?

Reich¹,

Brumberg²,

Pozzi³

et al. 2016

Brain

134

132

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*These authors contributed equally to this work.Thalamic deep brain stimulation is a mainstay treatment for severe and drug-refractory essential tremor, but postoperative management may be complicated in some patients by a progressive cerebellar syndrome including gait ataxia, dysmetria, worsening of intention tremor and dysarthria. Typically, this syndrome manifests several months after an initially effective therapy and necessitates frequent adjustments in stimulation parameters. There is an ongoing debate as to whether progressive ataxia reflects a delayed therapeutic failure due to disease progression or an adverse effect related to repeated increases of stimulation intensity. In this study we used a multimodal approach comparing clinical stimulation responses, modelling of volume of tissue activated and metabolic brain maps in essential tremor patients with and without progressive ataxia to disentangle a disease-related from a stimulation-induced aetiology. Ten subjects with stable and effective bilateral thalamic stimulation were stratified according to the presence (five subjects) of severe chronic-progressive gait ataxia. We quantified stimulated brain areas and identified the stimulation-induced brain metabolic changes by multiple 18 F-fluorodeoxyglucose positron emission tomography performed with and without active neurostimulation. Three days after deactivating thalamic stimulation and following an initial rebound of symptom severity, gait ataxia had dramatically improved in all affected patients, while tremor had worsened to the presurgical severity, thus indicating a stimulation rather than disease-related phenomenon. Models of the volume of tissue activated revealed a more ventrocaudal stimulation in the (sub)thalamic area of patients with progressive gait ataxia. Metabolic maps of both patient groups differed by an increased glucose uptake in the cerebellar nodule of patients with gait ataxia. Our data suggest that chronic progressive gait ataxia in essential tremor is a reversible cerebellar syndrome caused by a maladaptive response to neurostimulation of the (sub)thalamic area. The metabolic signature of progressive gait ataxia is an activation of the cerebellar nodule, which may be caused by inadvertent current spread and antidromic stimulation of a cerebellar outflow pathway originating in the vermis. An anatomical candidate could be the ascending limb of the uncinate tract in the subthalamic area. Adjustments in programming and precise placement of the electrode may prevent this adverse effect and help fine-tuning deep brain stimulation to ameliorate tremor without negative cerebellar signs.

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“…Es In einem Magnetresonanztomographen kann man nicht laufen, um so wichtiger ist der Nachweis, dass identische kortikale und subkortikale Lokomotionszentren, wie sie sich bei realer Lokomotion im PET darstellen, denen der vorgestellten, imaginierten, Lokomotion im fMRI entsprechen [9]. Dies ermöglicht reliable Gruppenvergleiche der unterschiedlichen Lokomotionsstörungen im fMRI bei neurodegenerativen Erkrankungen wie Parkinson oder progressiver supranukleärer Blicklähmung (Jahn und Zwergal, in diesem Heft).…”

Section: Einführung Zum Themaunclassified

Funktionelle Bildgebung in der Neurologie

Weiller

Brandt²

2010

Nervenarzt

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Real versus imagined locomotion: A [18F]-FDG PET-fMRI comparison

Cited by 356 publications

References 41 publications

Walking execution is not affected by divided attention in patients with multiple sclerosis with no disability, but there is a motor planning impairment

Walking execution is not affected by divided attention in patients with multiple sclerosis with no disability, but there is a motor planning impairment

Progressive gait ataxia following deep brain stimulation for essential tremor: adverse effect or lack of efficacy?

Funktionelle Bildgebung in der Neurologie

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