Real-world Adherence and Persistence with Bisphosphonate Therapy in Postmenopausal Women: A Systematic Review

Factors Associated With Adherence to Osteoporosis Medications Among Male Veterans

“…In this large cohort study of male Veterans, less than one-third of patients were adherent with a 5-year course for oral bisphosphonates, with nearly 80% discontinuing within 3 years. These numbers are comparable to prior studies in women; a systematic review identified 40-85% of women were adherent at 1 year and 26-72% had discontinued their medication by 1 year [14]. One study evaluated adherence over 5 years and found 23% of women (n=111) had an annual adherence of MPR > 0.80 [15].…”

“…These numbers are comparable to prior studies in women; a systematic review identified 40% to 85% of women were adherent at 1 year and 26% to 72% had discontinued their medication by 1 year. (14) One study evaluated adherence over 5 years and found 23% of women (n = 111) had an annual adherence of MPR ≥ 0.80. (15) However, it may be difficult to compare across studies depending on the time horizon or censoring strategy because there are several accepted ways of calculating MPR.…”

Porous Bone Increases the Risk of Posterior Mandibular Implant Failure

“…Clinicians may not know which patients have osteoporosis because many do not get bone mineral density evaluations in addition to the lack of compliance for taking antiresorptive medications. 16,17 Therefore, because of the lack of confirmation of the patient's BMD status, osteoporosis was not included in this evaluation. In the failed group, we did have documentation that 30% of the patients had osteoporosis.…”

A Mixed Methods Study Exploring Older Womens' Attitudes Toward Osteoporosis Medications: Adapting a Health Communication Framework

“…18 In a recent systematic review, after 1 year of BP use, persistence (time between initiation and discontinuation of medication) ranged from 28% to 74%. 19 Decision making regarding BP use is complex. Adults may lack awareness of the seriousness of OP and the associated risk of fractures, [20][21][22] and many are unaware of the morbidity and mortality risks associated with major fractures.…”