2020
DOI: 10.21037/cco-20-111
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Real-world assessment of the effect of impact of tumor size on pathological complete response rates in triple negative breast cancer after neoadjuvant chemotherapy

Abstract: Background: Triple negative breast cancer (TNBC) is characterized rapid tumor growth, and increased metastatic potential compared to other breast cancer subtypes. However, pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) can predict patients with a better prognosis. Clinical predictors of pCR such as tumor size (TS) are controversial. This study aims to evaluate the influence of TS on achieving pCR, and the associated survival outcomes. Methods: Medical records from 310 TNBC patients tre… Show more

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Cited by 14 publications
(10 citation statements)
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“…Table 1 presents characteristics of included studies [ 19 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ]. Three studies were based on pooled data from clinical trials [ 32 , 43 , 51 ].…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Table 1 presents characteristics of included studies [ 19 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ]. Three studies were based on pooled data from clinical trials [ 32 , 43 , 51 ].…”
Section: Resultsmentioning
confidence: 99%
“…Hazard ratios less than 1 show favourable outcomes in early-onset age group; hazard ratios greater than 1 show poorer outcomes in early-onset age group. References [ 13 , 22 , 25 , 27 , 29 , 30 , 33 , 40 , 42 , 48 , 49 ]. Abbreviations: CI = confidence interval; HR = hazard ratio.…”
Section: Figurementioning
confidence: 99%
“…All of these lines of research would benefit from prospective studies with higher power and more diverse populations in case of genetic differences between ethnic groups. Finally, since genomic data has been useful to predict survival outcomes and to tailor adjuvant treatment in hormonal receptor positive breast cancer, future research should focus on models incorporating clinical data to allow us to personalize curative treatment in TNBC (14).…”
Section: Editorialmentioning
confidence: 99%
“…One of the most important biomarkers is HER2 oncogene, which is a part of the message path (Signal Transduction Pathway). This protein is involved in the cell growth and plays a key role in the shift towards malignancy (6,7). Different expression levels of HER2 gene in normal and malignant cells have made HER2 to act as an ideal biomarker for therapeutic purposes (3,8).…”
Section: Introductionmentioning
confidence: 99%