Real-world clinical validity of cardiac magnetic resonance tissue tracking in primitive hypertrophic cardiomyopathy

Ruscitti

Cannizzaro³

et al. 2022

Sci Rep

Self Cite

Systemic sclerosis (SSc) is an uncommon autoimmune disease. Aim of the study was to detect the occult cardiac involvement in asymptomatic SSc patients of recent onset (indicative of a more aggressive disease) with unenhanced Cardiac Magnetic Resonance (CMR). Our historical prospective study included naïve SSc patients of recent onset. Modified Rodnan Skin Score (mRSS) and Scleroderma Clinical Trial Consortium Damage Index (SCTC-DI) were calculated. Cardiac volumes and global myocardial strain were assessed and also compared with healthy group values. Pericardial involvement was further recorded. Thirty-one patients met inclusion criteria (54 ± 12 years; 1 M). Mean duration of disease was 6.8 years. All patients showed preserved systolic function. Higher incidence of pericardial involvement was founded in patients with disease accrual damage (OR: 9.6, p-value 0.01). Radial and longitudinal strain values resulted significantly different between healthy and SSc patients. GRS and GLS showed an independent predictive validity on damage accrual (HR: 1.22 and 1.47, respectively). Best C-index for disease progression was reached when strain values and pericardial evaluation were added to conventional risk factors (0.97, p-value: 0.0001). Strain analysis by CMR-TT may show a high capability both in identifying early cardiac involvement and stratifying its clinical aggressiveness, regardless of the standard damage indices and CMR contrast-dependent biomarker.

“…Taking together these observations, a better comprehension of all strain values' mechanical aspects therefore results necessary to reach a more profound knowledge of HD 35 .…”

Section: Discussionmentioning

confidence: 99%

Unenhanced Cardiac Magnetic Resonance may improve detection and prognostication of an occult heart involvement in asymptomatic patients with systemic sclerosis

Ruscitti

Cannizzaro³

et al. 2022

Sci Rep

Self Cite

“…Different studies stress the potentiality of strain analysis, although: (i) a higher feasibility seems most related to the level of reader expertise [ 100 ]; (ii) different software could be used for strain analysis, producing different values [ 101 ]. However, recent software with machine learning implementation could represent a potential aid in reducing interobserver variability [ 102 ].…”

Section: Cmr and Ccta Imagingmentioning

confidence: 99%

Heart Failure and Cardiomyopathies: CT and MR from Basics to Advanced Imaging

Cannizzaro²,

et al. 2022

Diagnostics

Since 1997, heart failure (HF) has been designated as a new epidemic. However, it is not easy to find a proper definition since different descriptors are used in clinical practice. Moreover, HF is not a single clinical entity, and there is a close relationship between HF and all cardiomyopathies (CMs). This leads us to also consider accuracy in the characterization of CMs, which is essential to define the therapeutic process of HF patients. This narrative review aims to describe the main mechanisms leading to HF in different CMs, as well as the current diagnostic and prognostic advantages deriving from advanced imaging in the cardiac field.

Section: Li-radsmentioning

confidence: 99%

“…While the major criteria should always be satisfied, ancillary features, such as restricted diffusion (Figure 6), could be used at the discretion of the radiologist to increase or decrease the category, except to upgrade an observation from LR-4 to LR-5 [149][150][151]. While the major criteria should always be satisfied, ancillary features, such as restricted diffusion (Figure 6), could be used at the discretion of the radiologist to increase or decrease the category, except to upgrade an observation from LR-4 to LR-5 [149][150][151]. While the major criteria should always be satisfied, ancillary features, such as restricted diffusion (Figure 6), could be used at the discretion of the radiologist to increase or decrease the category, except to upgrade an observation from LR-4 to LR-5 [149][150][151].…”

Section: Ct/mri Categoriesmentioning

confidence: 99%

“…While the major criteria should always be satisfied, ancillary features, such as restricted diffusion (Figure 6), could be used at the discretion of the radiologist to increase or decrease the category, except to upgrade an observation from LR-4 to LR-5 [149][150][151]. While the major criteria should always be satisfied, ancillary features, such as restricted diffusion (Figure 6), could be used at the discretion of the radiologist to increase or decrease the category, except to upgrade an observation from LR-4 to LR-5 [149][150][151]. The categories LR-1 (definitely benign) and LR-2 (probably benign) include simple cysts or nodules, <20 mm in size, that do not show features of malignancy.…”

Section: Ct/mri Categoriesmentioning

confidence: 99%

See 1 more Smart Citation

A Narrative Review on LI-RADS Algorithm in Liver Tumors: Prospects and Pitfalls

et al. 2022

Self Cite

Liver cancer is the sixth most detected tumor and the third leading cause of tumor death worldwide. Hepatocellular carcinoma (HCC) is the most common primary liver malignancy with specific risk factors and a targeted population. Imaging plays a major role in the management of HCC from screening to post-therapy follow-up. In order to optimize the diagnostic-therapeutic management and using a universal report, which allows more effective communication among the multidisciplinary team, several classification systems have been proposed over time, and LI-RADS is the most utilized. Currently, LI-RADS comprises four algorithms addressing screening and surveillance, diagnosis on computed tomography (CT)/magnetic resonance imaging (MRI), diagnosis on contrast-enhanced ultrasound (CEUS) and treatment response on CT/MRI. The algorithm allows guiding the radiologist through a stepwise process of assigning a category to a liver observation, recognizing both major and ancillary features. This process allows for characterizing liver lesions and assessing treatment. In this review, we highlighted both major and ancillary features that could define HCC. The distinctive dynamic vascular pattern of arterial hyperenhancement followed by washout in the portal-venous phase is the key hallmark of HCC, with a specificity value close to 100%. However, the sensitivity value of these combined criteria is inadequate. Recent evidence has proven that liver-specific contrast could be an important tool not only in increasing sensitivity but also in diagnosis as a major criterion. Although LI-RADS emerges as an essential instrument to support the management of liver tumors, still many improvements are needed to overcome the current limitations. In particular, features that may clearly distinguish HCC from cholangiocarcinoma (CCA) and combined HCC-CCA lesions and the assessment after locoregional radiation-based therapy are still fields of research.