Real-world database investigating the association between diabetes mellitus and herpes zoster in Taiwan

Lai, Shih‐Wei; Lin, Cheng‐Li; Liao, Kuan‐Fu

doi:10.1097/md.0000000000015463

Cited by 16 publications

(9 citation statements)

References 21 publications

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“…Diabetes, malignancies, chronic kidney disease/uremia, chronic obstructive pulmonary disease, and peptic ulcer disease were all associated with a significantly higher risk of HZ than the general population in most studies (range of HRs: 1.17-8.46) [13,14,18,[20][21][22][23][24][25][26][27]. The potential association was weaker in persons with depression, psychiatric disease, hyperlipidemia, hypertension, as well as those post-general anesthesia (range of HRs: 1.11-1.29) [20,25,26,28,29]. Conversely, systemic steroid use in patients with psoriasis was associated with a significantly reduced risk of HZ (HR: 0.6, 95% CI: 0.44-0.81) [30], as was radical prostatectomy and hormone therapy in patients with prostate cancer (HR: 0.60, 95% CI: 0.44-0.81) [31].…”

Section: The Risk Of Hz In Patients With Other Co-morbiditiesmentioning

confidence: 94%

A systematic literature review to assess the burden of herpes zoster disease in China

Yin

Oorschot

Jiang

et al. 2020

Expert Review of Anti-infective Therapy

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Introduction: Herpes zoster (HZ) or shingles occurs as a result of reactivation after a primary infection with varicella zoster virus (chickenpox). The burden of HZ in older adults in China is not well understood. We conducted a systematic literature review to understand the burden of disease related to HZ, its complications, and associated costs in China. Areas covered: Using publications retrieved from Chinese and English literature databases, we described incidence and prevalence of HZ, occurrence of HZ-related complications, and costs associated with HZ in mainland China, Taiwan, and Hong Kong. Expert opinion: The data, although limited, indicate that the burden of disease due to HZ is substantial in China, with incidence rates that are comparable to the rest of the world. Recently, an adjuvanted recombinant HZ vaccine was approved for use in China. Disease prevention is likely to reduce the burden of disease, with potentially significant economic benefits. However, understanding the public health impact of vaccination in China will require extensive baseline information about incidence, complication rates, and associated costs. This review gives an overview of available research, but also reveals existing gaps. Well-designed observational studies are needed to quantify the total burden of disease and potential impact of prevention through vaccination.

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Section: The Risk Of Hz In Patients With Other Co-morbiditiesmentioning

confidence: 94%

A systematic literature review to assess the burden of herpes zoster disease in China

Yin

Oorschot

Jiang

et al. 2020

Expert Review of Anti-infective Therapy

View full text Add to dashboard Cite

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“…Table 1 demonstrated that 5 eligible cohort studies met the inclusion criteria. [ 11 – 15 ] The incidence of herpes zoster in patients with diabetes mellitus varied greatly between studies, ranging from 2.11 per 1000 person-years to 9.38 per 1000 person-years. The overall incidence of herpes zoster in patients with diabetes mellitus was 7.22 per 1000 person-years.…”

Section: Resultsmentioning

confidence: 99%

“…Patients aged ≥65 in diabetes group had the highest incidence rate of herpes zoster (11.91 per 1000 person-years) (Table 2 ). [ 11 , 13 ]…”

Section: Resultsmentioning

confidence: 99%

“…[ 5 – 7 ] Impaired immunological function has placed these patients at risk for developing a variety of infections including herpes zoster. [ 8 – 11 ]…”

Section: Introductionmentioning

confidence: 99%

“… ∗ Incidence rate ratio: diabetes mellitus versus non-diabetes mellitus including 2 eligible studies (Lai et al and Suaya et al). [ 11 , 13 ] …”

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The incidence of herpes zoster in patients with diabetes mellitus

et al. 2021

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The research has correlated the risk factors of herpes zoster with some chronic diseases. This meta-analysis aimed to assess the incidence of herpes zoster in patients with diabetes mellitus. We conducted a literature search using Web of Science and PubMed for articles published from January 1, 2000 to December 31, 2019. The incidence rate ratio and 95% confidence interval for herpes zoster associated with diabetes mellitus was calculated. We included 5 cohort studies for a meta-analysis. The pooled incidences of herpes zoster in patients with diabetes mellitus and in patients without diabetes mellitus were 7.22 and 4.12 per 1000 person-years. The overall risk of developing herpes zoster was significantly higher in patients with diabetes mellitus when compared to those with no diabetes mellitus (incidence rate ratio = 1.60, 95% confidence interval = 1.33–1.93). Patients with diabetes mellitus are substantially at increased risk for the development of herpes zoster. Patients with diabetes mellitus should take into consideration the vaccination to prevent herpes zoster.

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Burden of Herpes Zoster in Adult Patients with Underlying Conditions: Analysis of German Claims Data, 2007–2018

Batram

Witte

Schwarz

et al. 2021

Dermatol Ther (Heidelb)

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Introduction Several chronic underlying conditions (UCs) are known to be risk factors for developing herpes zoster (HZ) and to increase the severity of HZ and its risk of recurrence. The aim of this study was to investigate the incidence and recurrence of HZ in adult patients with one or multiple UCs. Methods A retrospective cohort study based on claims data representing 13% of the statutory health insurance population from 2007 to 2018 in Germany was performed. Patients aged ≥ 18 years were included when at least one of the following UCs was diagnosed: asthma, chronic heart failure, chronic obstructive pulmonary disease (COPD), coronary heart disease (CHD), depression, diabetes mellitus type 1 or 2, and rheumatoid arthritis (RA). Exact matching was used to account for differences in the distribution of age and sex between the case and matched control cohorts. Multi-morbidity was considered in sensitivity analyses by analyzing patients with only one UC. Results Patients with asthma, CHD, COPD, depression, and RA had, on average, a 30% increased risk of developing acute HZ compared to patients without any UC. RA was found to have the highest odds ratio among these conditions, varying from 1.37 to 1.57 for all age groups. Patients with depression also showed a high risk of developing HZ. Analysis of recurrence indicated that patients with at least one UC in the age groups 18–49 years and 50–59 years had the highest risk for a recurrent HZ. After experiencing a first recurrence, patients, regardless of age group, had a two- to threefold higher risk for a second recurrence. Conclusion This study of representative claims data shows a higher HZ incidence and recurrence frequency in patients with UCs. These results provide relevant information for national health care guidelines and disease management programs. Supplementary Information The online version contains supplementary material available at 10.1007/s13555-021-00535-7.

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Real-world database investigating the association between diabetes mellitus and herpes zoster in Taiwan

Cited by 16 publications

References 21 publications

A systematic literature review to assess the burden of herpes zoster disease in China

A systematic literature review to assess the burden of herpes zoster disease in China

The incidence of herpes zoster in patients with diabetes mellitus

Burden of Herpes Zoster in Adult Patients with Underlying Conditions: Analysis of German Claims Data, 2007–2018

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