Real-World Outcomes of Patients with Acute Myeloid Leukemia in Taiwan: A Nationwide Population-Based Study, 2011-2015

Wang, Chen Yu; Huang, Huai-Hsuan; Chen, Ho Min; Hsiao, Fei‐Yuan; Ko, Bor‐Sheng

doi:10.1016/j.clml.2021.03.010

Clinical Lymphoma Myeloma and Leukemia

2021

DOI: 10.1016/j.clml.2021.03.010

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Real-World Outcomes of Patients with Acute Myeloid Leukemia in Taiwan: A Nationwide Population-Based Study, 2011-2015

Chen Yu Wang

Huai-Hsuan Huang

Ho Min Chen

et al.

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2024

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The influence of hospital volume and physician volume on early mortality in acute promyelocytic leukemia patients

Wu,

Yeh,

Tsai

et al. 2024

Ann Hematol

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Acute promyelocytic leukemia (APL) is a highly curable hematologic malignancy in the era of all-trans retinoic acid (ATRA) combination treatment. However, only a modest change in early mortality rate has been observed despite the wide availability of ATRA. In addition to the clinical characteristics of APL patients, studies on the hospital volume-outcome relationship and the physician volume-outcome relationship remained limited. We aim to evaluate the association between hospital and physician volume and the early mortality rate among APL patients. The patients were collected from Taiwan’s National Health Insurance Research Database (NHIRD). Early mortality is defined as death within 30 days of diagnosis. Patients were categorized into four groups according to individual cumulative hospital and physician volume. The risk of all-cause mortality in APL patients with different cumulative volume groups was compared using a Cox proportional hazard model. The probability of overall survival was estimated using the Kaplan–Meier method. All 741 patients were divided into four quartile volume groups. In the multivariate analysis, only physician volume was significantly associated with early mortality rate. The physician volume of the highest quartile was a protective factor for early mortality compared with the physician volume of the lowest quartile (HR 0.10, 95% CI 0.02–0.65). Hospital characteristics were not associated with early mortality. In the sensitivity analyses, the results remained consistent using two other different definitions of early mortality. Higher physician volume was independently associated with lower early mortality, while hospital volume was not. Enhancing the clinical expertise of low-volume physicians may ensure better outcomes.

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The influence of hospital volume and physician volume on early mortality in acute promyelocytic leukemia patients

Wu,

Yeh,

Tsai

et al. 2024

Ann Hematol

View full text Add to dashboard Cite

show abstract

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Real-World Outcomes of Patients with Acute Myeloid Leukemia in Taiwan: A Nationwide Population-Based Study, 2011-2015

Cited by 1 publication

References 40 publications

The influence of hospital volume and physician volume on early mortality in acute promyelocytic leukemia patients

The influence of hospital volume and physician volume on early mortality in acute promyelocytic leukemia patients

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