2020
DOI: 10.31487/j.cor.2020.07.11
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Real World Patterns of PSA Response and Survival with Abiraterone and Enzalutamide in Metastatic Castrate Resistant Prostate Cancer (mCRPC)

Abstract: Background: We investigated our institution’s mCRPC enzalutamide or abiraterone patients examining PSA responses and impact of sequencing of these drugs. Methods: All enzalutamide / abiraterone mCRPC patients (2011-2018) were included. Rates of PSA >50% response (PSA50) were compared. Time to treatment failure (TTF) and overall survival (OS) was analysed as per lines of previous therapy and timing of chemotherapy. Results: 363 patients included (Enza n=236, Abi n=127), with 15.6 months median follow-up. PSA… Show more

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“…Specifically, the OS with enzalutamide was about 30 months with or without prior chemotherapy, which is similar to results from AFFIRM and PREVAIL. PSA responses for enzalutamide seen in our study appear to be similar to other retrospective trials mentioned above (9,10). Patients receiving abiraterone however appeared to have a much poorer survival outcome; only 15 months and 7 months for no chemotherapy and prior chemotherapy respectively.…”
Section: Discussionsupporting
confidence: 88%
“…Specifically, the OS with enzalutamide was about 30 months with or without prior chemotherapy, which is similar to results from AFFIRM and PREVAIL. PSA responses for enzalutamide seen in our study appear to be similar to other retrospective trials mentioned above (9,10). Patients receiving abiraterone however appeared to have a much poorer survival outcome; only 15 months and 7 months for no chemotherapy and prior chemotherapy respectively.…”
Section: Discussionsupporting
confidence: 88%