Real world utilization of the myositis autoantibody panel

Maheswaranathan, Mithu; Johannemann, Andrew; Weiner, Jason; Jessee, Ryan C.; Eudy, Amanda M; Criscione-Schreiber, Lisa G

doi:10.1007/s10067-021-05658-y

Cited by 8 publications

(1 citation statement)

References 28 publications

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“…The proportion is only slightly higher than reported in the literature for healthy subjects [ 12 , 13 ], however, it should be considered that the selection criteria used in this study were very strict, excluding patients with suggestive autoimmune features. A recent, retrospective study evaluated the prevalence of MSA in a cohort of patients with a suspicion of underlying IIM, finding positivity for MSA in 18% of patients [ 32 ]. In this cohort, as reported in our study, the most common MSA was anti-Mi2.…”

Section: Discussionmentioning

confidence: 99%

Myositis-Specific and Myositis-Associated Antibodies in Fibromyalgia Patients: A Prospective Study

et al. 2023

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Fibromyalgia (FM) is a common rheumatologic disorder characterised by widespread muscular pain. Myalgia is also a common clinical feature in Connective Tissue Disease (CTD), and FM should be studied for the concomitant presence of a CTD. The aim of this study is to evaluate the prevalence of Myositis-Specific and Myositis-Associated Antibodies (MSA/MAA) in a cohort of FM patients. We enrolled 233 consecutive FM patients (defined according to the 2016 criteria) that did not report clinical signs of autoimmune disorders and followed them for at least one year. The patients were tested for MSA/MAA with immunoblotting. FM patients were seropositive for Antinuclear Antibodies (ANA) in 24% of cases, for MSA in 9%, and for MAA in 6%. A specific diagnosis of CTD was made in 12 patients (5.2%), namely, 5 cases of primary Sjögren’s Syndrome and 7 of Idiopathic Inflammatory Myopathy. Seropositive patients showed clinical features similar to those who were seronegative at baseline. A CTD diagnosis was associated with ANA positivity (p = 0.03, X2 4.9), the presence of a speckled pattern (p = 0.02, X2 5.3), positivity for MAA (p = 0.004, X2 8.1), and MSA (p = 0.003, X2 9.2). In conclusion, a non-negligible proportion of FM patients may be seropositive for MSA/MAA, and that seropositivity might suggest a diagnosis of CTD.

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Section: Discussionmentioning

confidence: 99%

Myositis-Specific and Myositis-Associated Antibodies in Fibromyalgia Patients: A Prospective Study

et al. 2023

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Rhabdomyolysis-associated acute kidney injury in a teenager: Answers

et al. 2022

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Statin-induced autoimmune myositis: a proposal of an “experience-based” diagnostic algorithm from the analysis of 69 patients

et al. 2023

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Statin-induced autoimmune myositis (SIAM) represents a rare clinical entity that can be triggered by prolonged statin treatment. Its pathogenetic substrate consists of an autoimmune-mediated mechanism, evidenced by the detection of antibodies directed against the 3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR Ab), the target enzyme of statin therapies. To facilitate the diagnosis of nuanced SIAM clinical cases, the present study proposes an “experience-based” diagnostic algorithm for SIAM. We have analyzed the clinical data of 69 patients diagnosed with SIAM. Sixty-seven patients have been collected from the 55 available and complete case records regarding SIAM in the literature; the other 2 patients represent our direct clinical experience and their case records have been detailed. From the analysis of the clinical features of 69 patients, we have constructed the diagnostic algorithm, which starts from the recognition of suggestive symptoms of SIAM. Further steps provide for CK values dosage, musculoskeletal MR, EMG/ENG of upper-lower limbs and, Anti-HMGCR Ab testing and, where possible, the muscle biopsy. A global evaluation of the collected clinical features may suggest a more severe disease in female patients. Atorvastatin proved to be the most used hypolipidemic therapy.

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Real world utilization of the myositis autoantibody panel

Cited by 8 publications

References 28 publications

Myositis-Specific and Myositis-Associated Antibodies in Fibromyalgia Patients: A Prospective Study

Myositis-Specific and Myositis-Associated Antibodies in Fibromyalgia Patients: A Prospective Study

Rhabdomyolysis-associated acute kidney injury in a teenager: Answers

Statin-induced autoimmune myositis: a proposal of an “experience-based” diagnostic algorithm from the analysis of 69 patients

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