Real-World Vaccine Research and Clinical Practice

Kumar, Anika; Acharya, Nisha R.

doi:10.1001/jamaophthalmol.2024.1049

Cited by 1 publication

(1 citation statement)

References 8 publications

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“…Several limitations of this study should be acknowledged, including its retrospective design and reliance on diagnostic codes in the NHIS database for data collection, which may lead to the underestimation of outcomes due to under-reporting. Misclassification bias may be another important limitation of population-based studies using health-claim databases [ 21 ]. The post-vaccination period might be heterogeneous in terms of uveitis risk, owing to subsequent vaccinations, despite having a smaller effect than the first one in previous studies [ 12 , 13 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Risk of Post-COVID-19 Uveitis and Risk Modification by Vaccination: A Nationwide Retrospective Cohort Study

Kim,

Ahn

2024

Vaccines

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This study aimed to evaluate the risk of uveitis, one of the most common ocular manifestations of COVID-19, in individuals with a history of uveitis and COVID-19 infection while discriminating the effects of COVID-19 infection and vaccinations. We analyzed nationwide data from 235,228 individuals with a history of uveitis prior to COVID-19 infection and evaluated incidences and hazard ratios (HRs) of post-COVID-19 uveitis for different post-infection periods, including early- (within 30 days) and delayed-onset ones. The cumulative incidences of post-infection uveitis at 3, 6, and 12 months were calculated as 8.5%, 11.8%, and 14.0%, respectively. The HR of post-COVID-19 uveitis was 1.21 (95% confidence interval [CI]: 1.07–1.37) and was particularly higher in the early-onset period (1.42, 95% CI: 1.24–1.61). Vaccinated individuals showed a modestly elevated risk of uveitis relative to pre-infection, while unvaccinated ones exhibited substantially higher risks in the early-onset period: the HR of post-infection uveitis before vaccination was 3.61 (95% CI: 1.35-9.66), whereas after vaccination, it was 1.21 (95% CI: 1.05–1.39). COVID-19 infection was associated with a higher risk of uveitis, which was mitigated by vaccination. Vigilance in the monitoring of uveitis is warranted for recently COVID-19-infected individuals with a history of uveitis, particularly unvaccinated individuals.

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