Realistic reference adult and paediatric phantom series for internal and external dosimetry

Stabin, Michael G.; Emmons, Mary Ann; Segars, W. Paul; Fernald, Michael J.

doi:10.1093/rpd/ncr383

Cited by 27 publications

(25 citation statements)

References 6 publications

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“…36,37 We performed a validation step for the GATE simulations on internal dosimetry using an adult XCAT reference model and a model representing a 5-yr-old boy and by calculating the SAFs for a photon energy range of 10 keV-3 MeV. 38 This procedure validated the tools used in this study for further extracting the S-values and SADRs for several radiopharmaceuticals.…”

Section: A MC Simulationsmentioning

confidence: 91%

A personalized, Monte Carlo‐based method for internal dosimetric evaluation of radiopharmaceuticals in children

et al. 2018

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Because pediatric radiopharmaceutical dosimetric estimates demonstrate large variation due to the patient's anatomical characteristics, personalized data should be considered. Using our SADR method in a larger population of phantoms and for a variety of radiopharmaceuticals could enhance the personalization of dosimetry in pediatric nuclear medicine. The proposed methodology provides the advantage of creating time-dependent organ dose rate curves.

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Section: A MC Simulationsmentioning

confidence: 91%

A personalized, Monte Carlo‐based method for internal dosimetric evaluation of radiopharmaceuticals in children

et al. 2018

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“…Format types include stylized (mathematical equation‐based), voxel (segmented CT/MR images), and hybrid (NURBS and polygon mesh surfaces). Morphometric categories include reference (small library of phantoms by age at 50th height/weight percentile), patient‐dependent (larger library of phantoms at various combinations of height/weight), patient sculpted (phantoms altered to match the patient's unique body contour with proportional changes to internal anatomy), and finally, patient‐specific (an exact representation of the patient with respect to both body contour and internal anatomy) . A given computational phantom may thus come in different combinations of both format type and morphometric category, each with its own strengths and weaknesses.…”

Section: Introductionmentioning

confidence: 99%

Assessment of different patient‐to‐phantom matching criteria applied in Monte Carlo–based computed tomography dosimetry

et al. 2017

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Overall, these data suggest that matching a patient to a computational phantom in a library is superior to matching to a reference phantom. Water equivalent diameter is the superior matching metric, but it is less feasible to implement in a clinical and retrospective setting. For these reasons, height-and-weight matching is an acceptable and reliable method for matching a patient to a member of a computational phantom library with regard to CT dosimetry.

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“…Thus, simulating RF field behavior during breast MRI scans would ideally incorporate a female whole-body voxel model into the FDTD mesh. Although several adult female body models are available to the research community, all are oriented in the standing or supine positions; [12–16] unfortunately, these orientations limit the existing voxel models’ applicability for simulating the filling factor of breast RF coils designed for women in the prone position, as is typically performed with MRI to avoid respiratory artifacts. [17, 18] …”

Section: Introductionmentioning

confidence: 99%

Automated modification and fusion of voxel models to construct body phantoms with heterogeneous breast tissue: Application to MRI simulations

Rispoli

Wright

Malloy

et al. 2017

JBGC

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Background Human voxel models incorporating detailed anatomical features are vital tools for the computational evaluation of electromagnetic (EM) fields within the body. Besides whole-body human voxel models, phantoms representing smaller heterogeneous anatomical features are often employed; for example, localized breast voxel models incorporating fatty and fibroglandular tissues have been developed for a variety of EM applications including mammography simulation and dosimetry, magnetic resonance imaging (MRI), and ultra-wideband microwave imaging. However, considering wavelength effects, electromagnetic modeling of the breast at sub-microwave frequencies necessitates detailed breast phantoms in conjunction with whole-body voxel models. Methods Heterogeneous breast phantoms are sized to fit within radiofrequency coil hardware, modified by voxel-wise extrusion, and fused to whole-body models using voxel-wise, tissue-dependent logical operators. To illustrate the utility of this method, finite-difference time-domain simulations are performed using a whole-body model integrated with a variety of available breast phantoms spanning the standard four tissue density classifications representing the majority of the population. Results The software library uses a combination of voxel operations to seamlessly size, modify, and fuse eleven breast phantoms to whole-body voxel models. The software is publicly available on GitHub and is linked to the file exchange at MATLAB® Central. Simulations confirm the proportions of fatty and fibroglandular tissues in breast phantoms have significant yet predictable implications on projected power deposition in tissue. Conclusions Breast phantoms may be modified and fused to whole-body voxel models using the software presented in this work; user considerations for the open-source software and resultant phantoms are discussed. Furthermore, results indicate simulating breast models as predominantly fatty tissue can considerably underestimate the potential for tissue heating in women with substantial fibroglandular tissue.

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Realistic reference adult and paediatric phantom series for internal and external dosimetry

Cited by 27 publications

References 6 publications

A personalized, Monte Carlo‐based method for internal dosimetric evaluation of radiopharmaceuticals in children

A personalized, Monte Carlo‐based method for internal dosimetric evaluation of radiopharmaceuticals in children

Assessment of different patient‐to‐phantom matching criteria applied in Monte Carlo–based computed tomography dosimetry

Automated modification and fusion of voxel models to construct body phantoms with heterogeneous breast tissue: Application to MRI simulations

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