Realization of cellomics to dive into the whole-body or whole-organ cell cloud

Mitani, Tomoki T.; Susaki, Etsuo A.; Matsumoto, Katsuhiko; Ueda, Hiroki R.

doi:10.1038/s41592-024-02307-5

Nat Methods

2024

DOI: 10.1038/s41592-024-02307-5

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Realization of cellomics to dive into the whole-body or whole-organ cell cloud

Tomoki T. Mitani,

Etsuo A. Susaki,

Katsuhiko Matsumoto

et al.

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2024

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Cited by 2 publications

References 26 publications

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Tissue histology in 3D

2024

Nat Methods

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Tissue histology in 3D

2024

Nat Methods

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Unlocking the potential of large-scale 3D imaging with tissue clearing techniques

Susaki

2024

Microscopy

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The three-dimensional (3D) anatomical structure of living organisms is intrinsically linked to their functions, yet modern life sciences have not fully explored this aspect. Recently, the combination of efficient tissue clearing techniques and light-sheet fluorescence microscopy (LSFM) for rapid 3D imaging has improved access to 3D spatial information in biological systems. This technology has found applications in various fields, including neuroscience, cancer research, and clinical histopathology, leading to significant insights. It allows imaging of entire organs or even whole bodies of animals and humans at multiple scales. Moreover, it enables a form of spatial omics by capturing and analyzing cellome information, which represents the complete spatial organization of cells. While current 3D imaging of cleared tissues has limitations in obtaining sufficient molecular information, emerging technologies such as multi-round tissue staining and super-multicolor imaging are expected to address these constraints. 3D imaging using tissue clearing and light-sheet microscopy thus offers a valuable research tool in the current and future life sciences for acquiring and analyzing large-scale biological spatial information.

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Realization of cellomics to dive into the whole-body or whole-organ cell cloud

Cited by 2 publications

References 26 publications

Tissue histology in 3D

Tissue histology in 3D

Unlocking the potential of large-scale 3D imaging with tissue clearing techniques

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