Realizing tissue integration with supramolecular hydrogels

Feliciano, Antonio J.; Blitterswijk, Clemens van; Moroni, Lorenzo; Baker, Matthew B.

doi:10.1016/j.actbio.2021.01.034

Cited by 41 publications

(33 citation statements)

References 121 publications

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“…The experiment generally concluded a suitable scanning speed from 30 to 140 µm/s with an average optical power distributed from 2 to around 20 mW. To check the formation quality for complex hollow structures widely applied for cell proliferation [9], micro machinery [47] or microfluidic [48], a batch of scaffolds consisting of specific tetrahedrons and cubes was firstly fabricated and characterized (Figure 3b,e).…”

Section: Fabricating Hollow 3d Structures With Selected Spatial Resol...mentioning

confidence: 99%

“…However, conventional 3D-printed constructs have fallen short of expectations, mainly due to their bulky volume and inability to mimic the dynamic human tissues. Thereby, the shape-reconfigurable hydrogels emerge as a new scientific frontier for cancer treatment [6], wound healing [7], or biomimetic applications [8][9][10][11][12][13][14][15] acting similar to artificial muscles [11], grippers [12], actuators, active origami or machines [13], swellable scaffolds [14], organic electronics [15], microneedles [16,17], etc.…”

Section: Introductionmentioning

confidence: 99%

“…These smart hydrogel devices would ideally possess the embeddable volume and the reconfigurable morphology to be applied [9,10]. The composition of smart hydrogels re-defines the environment-to-hydrogel interactions, the controllability of responsive behavior [13], and the dynamic mechanical properties to a large extent.…”

Section: Introductionmentioning

confidence: 99%

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Four-Dimensional Stimuli-Responsive Hydrogels Micro-Structured via Femtosecond Laser Additive Manufacturing

Tao

Deng

et al. 2021

Micromachines

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Rapid fabricating and harnessing stimuli-responsive behaviors of microscale bio-compatible hydrogels are of great interest to the emerging micro-mechanics, drug delivery, artificial scaffolds, nano-robotics, and lab chips. Herein, we demonstrate a novel femtosecond laser additive manufacturing process with smart materials for soft interactive hydrogel micro-machines. Bio-compatible hyaluronic acid methacryloyl was polymerized with hydrophilic diacrylate into an absorbent hydrogel matrix under a tight topological control through a 532 nm green femtosecond laser beam. The proposed hetero-scanning strategy modifies the hierarchical polymeric degrees inside the hydrogel matrix, leading to a controllable surface tension mismatch. Strikingly, these programmable stimuli-responsive matrices mechanized hydrogels into robotic applications at the micro/nanoscale (<300 × 300 × 100 μm3). Reverse high-freedom shape mutations of diversified microstructures were created from simple initial shapes and identified without evident fatigue. We further confirmed the biocompatibility, cell adhesion, and tunable mechanics of the as-prepared hydrogels. Benefiting from the high-efficiency two-photon polymerization (TPP), nanometer feature size (<200 nm), and flexible digitalized modeling technique, many more micro/nanoscale hydrogel robots or machines have become obtainable in respect of future interdisciplinary applications.

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Section: Fabricating Hollow 3d Structures With Selected Spatial Resol...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Four-Dimensional Stimuli-Responsive Hydrogels Micro-Structured via Femtosecond Laser Additive Manufacturing

Tao

Deng

et al. 2021

Micromachines

View full text Add to dashboard Cite

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“…For load-bearing tissues, it is important to understand the correlations between structure and function to define tissue engineering design criteria. The viscoelastic property of cartilage derives from its extracellular matrix (ECM) composition that is made of water, collagen, and glycosaminoglycans [24][25][26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Additive-Free Gelatine-Based Devices for Chondral Tissue Regeneration: Shaping Process Comparison among Mould Casting and Three-Dimensional Printing

et al. 2022

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Gelatine is a well-known and extensively studied biopolymer, widely used in recent decades to create biomaterials in many different ways, exploiting its molecular resemblance with collagen, the main constituent of the extra-cellular matrix, from which it is derived. Many have employed this biopolymer in tissue engineering and chemically modified (e.g., gelatin methacryloyl) or blended it with other polymers (e.g., alginate) to modulate or increase its performances and printability. Nevertheless, little is reported about its use as a stand-alone material. Moreover, despite the fact that multiple works have been reported on the realization of mould-casted and three-dimensional printed scaffolds in tissue engineering, a clear comparison among these two shaping processes, towards a comparable workflow starting from the same material, has never been published. Herein, we report the use of gelatine as stand-alone material, not modified, blended, or admixed to be processed or crosslinked, for the realization of suitable scaffolds for tissue engineering, towards the two previously mentioned shaping processes. To make the comparison reliable, the same pre-process (e.g., the gelatin solution preparation) and post-process (e.g., freeze-drying and crosslinking) steps were applied. In this study, gelatine solution was firstly rheologically characterized to find a formulation suitable for being processed with both the shaping processes selected. The realized scaffolds were then morphologically, phisico-chemically, mechanically, and biologically characterized to determine and compare their performances. Despite the fact that the same starting material was employed, as well as the same pre- and post-process steps, the two groups resulted, for most aspects, in diametrically opposed characteristics. The mould-casted scaffolds that resulted were characterized by small, little-interconnected, and random porosity, high resistance to compression and slow cell colonization, while the three-dimensional printed scaffolds displayed big, well-interconnected, and geometrically defined porosity, high elasticity and recover ability after compression, as well as fast and deep cell colonization.

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“…The field of supramolecular gels is intriguing because of the multitude of compounds[ 1 , 2 ] and mixtures of compounds [3] which are able to form gels. This ever‐expanding library of compounds has provided many fascinating supramolecular gel systems with possible applications in regenerative medicine,[ 1 , 4 , 5 , 6 ] treatment of cancer,[ 1 , 7 ] environmental remediation,[ 8 , 9 , 10 , 11 , 12 ] imaging [1] as well as many others. The formation of the supramolecular gel occurs by immobilization of the solvent through weak interactions, such as hydrogen bonding, π‐π‐interactions, or metal coordination.…”

Section: Introductionmentioning

confidence: 99%

The Effect of the Side Chain on Gelation Properties of Bile Acid Alkyl Amides

2021

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Six bile acid alkyl amide derivatives were studied with respect to their gelation properties. The derivatives were composed of three different bile acids with hexyl or cyclohexyl side chains. The gelation behaviour of all six compounds were studied for 36 solvents with varying polarities. Gelation was observed mainly in aromatic solvents, which is characteristic for bile‐acid‐based low molecular weight gelators. Out of 108 bile acid‐solvent combinations, a total of 44 gel systems were formed, 28 of which from lithocholic acid derivatives, only two from deoxycholic acid derivatives, and 14 from cholic acid derivatives. The majority of the gel systems were formed from bile acids with hexyl side chains, contrary to the cyclohexyl group, which seems to be a poor gelation moiety. These results indicate that the spatial demand of the side chain is the key feature for the gelation properties of the bile acid amides.

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Realizing tissue integration with supramolecular hydrogels

Cited by 41 publications

References 121 publications

Four-Dimensional Stimuli-Responsive Hydrogels Micro-Structured via Femtosecond Laser Additive Manufacturing

Four-Dimensional Stimuli-Responsive Hydrogels Micro-Structured via Femtosecond Laser Additive Manufacturing

Additive-Free Gelatine-Based Devices for Chondral Tissue Regeneration: Shaping Process Comparison among Mould Casting and Three-Dimensional Printing

The Effect of the Side Chain on Gelation Properties of Bile Acid Alkyl Amides

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