Really smart bioconjugates of smart polymers and receptor proteins

Hoffman, Allan S.; Stayton, Patrick S.; Bulmuş, Volga; Chen, Guohua; Chen, Jingping; Cheung, Chuck; Chilkoti, Ashutosh; Ding, Zhongli; Dong, Liangchang; Fong, Robin B.; Lackey, Chantal A.; Long, Cynthia J.; Miura, Morikazu; Morris, John E.; Murthy, Niren; Nabeshima, Yoshikuni; Park, Tae Gwan; Press, Oliver W.; Shimoboji, Tsuyoshi; Shoemaker, Sara G.; Yang, Heung Joon; Monji, Nobuo; Nowinski, Robert C.; Cole, Carole Ann; Priest, John H.; Harris, J. Milton; Nakamae, Katsuhiko; Nishino, Takashi; Miyata, Takashi

doi:10.1002/1097-4636(20001215)52:4<577::aid-jbm1>3.3.co;2-x

Cited by 20 publications

(24 citation statements)

References 22 publications

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“…However, improvements are required in many areas, such as prevention of non-specific binding [302][303][304][305][306], sensitivity [307][308][309][310][311][312][313][314][315], site-specific conjugation [316][317][318], bioactivity [319][320][321][322], multiplexing [309,323], and reusability [324][325][326]. Some of these problems can be addressed by using different chemical surface modification approaches.…”

Section: Biosensing-detectionmentioning

confidence: 99%

Peptide-based biopolymers in biomedicine and biotechnology

Chow

Nunalee

Lim

et al. 2008

Materials Science and Engineering: R: Reports

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231

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Peptides are emerging as a new class of biomaterials due to their unique chemical, physical, and biological properties. The development of peptide-based biomaterials is driven by the convergence of protein engineering and macromolecular self-assembly. This review covers the basic principles, applications, and prospects of peptide-based biomaterials. We focus on both chemically synthesized and genetically encoded peptides, including poly-amino acids, elastin-like polypeptides, silk-like polymers and other biopolymers based on repetitive peptide motifs. Applications of these engineered biomolecules in protein purification, controlled drug delivery, tissue engineering, and biosurface engineering are discussed.

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Section: Biosensing-detectionmentioning

confidence: 99%

Peptide-based biopolymers in biomedicine and biotechnology

Chow

Nunalee

Lim

et al. 2008

Materials Science and Engineering: R: Reports

Self Cite

286

231

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“…50 In many cases, the change in the state of the polymer is reversible. Smart synthetic polymers may revolutionize improvements in tissue engineering scaffolds.…”

Section: 폴리머 제38권 제2호 2014년mentioning

confidence: 99%

Recent Applications of Polymeric Biomaterials and Stem Cells in Tissue Engineering and Regenerative Medicine

Lee

Yoo

Atala³

2014

Polymer Korea

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Tissue engineering and regenerative medicine strategies could offer new hope for patients with serious tissue injuries or end-stage organ failure. Scientists are now applying the principles of cell transplantation, material science, and engineering to create biological substitutes that can restore and maintain normal function in diseased or injured tissues/ organs. Specifically, creation of engineered tissue construct requires a polymeric biomaterial scaffold that serves as a cell carrier, which would provide structural support until native tissue forms in vivo. Even though the requirements for scaffolds may be different depending on the target applications, a general function of scaffolds that need to be fulfilled is biodegradability, biological and mechanical properties, and temporal structural integrity. The scaffold's internal architecture should also enhance the permeability of nutrients and neovascularization. In addition, the stem cell field is advancing, and new discoveries in tissue engineering and regenerative medicine will lead to new therapeutic strategies. Although use of stem cells is still in the research phase, some therapies arising from tissue engineering endeavors that make use of autologous adult cells have already entered the clinic. This review discusses these tissue engineering and regenerative medicine strategies for various tissues and organs.

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“…Hoffman and Stayton, leaders in the field of responsive polymer protein conjugates, have various publications that have applications as "molecular switches" and for enzyme recovery (34,54,(107)(108)(109)(110)(111). They have demonstrated that a polymer chain attached at a specific conjugation site can act as a "molecular switch" controlling enzyme activity through thermal or photoactive control (Figure 8).…”

Section: Stimuli-responsive Conjugates Stimuli-responsive Polymers (mentioning

confidence: 99%

Protein‐Polymer Conjugates

Briand¹,

Kumar²,

Kasi³

2011

Encyclopedia of Polymer Science and Technology

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This chapter focuses on the design and applications of protein‐polymer conjugates. Protein‐polymer conjugates are synthesized by conjugating a polymer chain or many polymer chains onto a protein. The site of conjugation, protein, polymer, and stoichiometry are important criteria when designing a protein‐polymer conjugate. The important structural aspects and functions of proteins, such as hierarchical structure and activity, are discussed. The various methods of site‐specific conjugation, “grafting to”, “grafting from” and cofactor reconstitution, are included along the pros and cons of each method. Conjugates synthesized by random conjugation are also discussed. The specific reactions used for protein attachment are not included, as numerous synthetic reviews exist; however, a broad overview of the field is presented. Novel conjugate structures can be synthesized by attaching synthetic peptide sequences onto polymers. In addition to design considerations, the range of applications from drug delivery systems to biosensors are discussed. This chapter aims to aid in furthering the knowledge and growth of the synergistic combination of proteins and polymers.

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Really smart bioconjugates of smart polymers and receptor proteins

Cited by 20 publications

References 22 publications

Peptide-based biopolymers in biomedicine and biotechnology

Peptide-based biopolymers in biomedicine and biotechnology

Recent Applications of Polymeric Biomaterials and Stem Cells in Tissue Engineering and Regenerative Medicine

Protein‐Polymer Conjugates

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