Reanalysis of cancer mortality using reconstructed organ-absorbed dose: J-EPISODE 1991‒2010

Furuta, Hiroshige; Kudo, Shinichi; Ishizawa, Noboru; Saigusa, Shin

doi:10.1088/1361-6498/ac3bc5

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…The value of the ERR/Gy in this model was then very close to those observed in the previously cited studies [26,43] and in the latest analysis of the United Kingdom Radiation Registry of Radiation Workers [46]. In US NPP workers, the ERR per 100 mGy for leukaemia other than CLL was slightly lower (0.15; 90% CI: −0.001; 0.31) [45], whereas, in Japanese NPP workers, it was negative but with very large statistical uncertainty (ERR/Gy = −0.42; 90%CI: −5.38, 7.59); therefore, these results remain statistically compatible with our findings [44].…”

Section: Leukaemia Excluding Cllsupporting

confidence: 89%

“…A recent analysis of solid cancer incidence in a British cohort of 172,452 radiation workers also reported a similar statistically significant estimate ERR/Sv= 0.52, 95% CI: 0.11; 0.96) [18]. In a Japanese cohort of 204,103 nuclear power plant workers, the ERR/Gy was 1.22 (90% CI: 0.24, 2.26) for all cancers excluding leukaemia [44]. By contrast, in a recent study of 135,193 US nuclear power plant workers included in the larger US Million Person Study, the ERR per Gy (95% CI) for mortality by solid cancers was 0.1 (−0.3; 0.5) [45].…”

Section: Mortality Analyses (Comparison With External Reference)mentioning

confidence: 66%

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Updated Mortality Analysis of SELTINE, the French Cohort of Nuclear Workers, 1968–2014

Olivier

Samson

Caër-Lorho

et al. 2022

Cancers

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Cohorts of nuclear workers are particularly relevant to study the health effects of protracted exposures to low doses at low dose-rates of ionizing radiation (IR). In France, a cohort of nuclear workers badge-monitored for external IR exposure has been followed-up for several decades. Its size and follow-up period have recently been extended. The present paper focuses on mortality from both cancer and non-cancer diseases in this cohort. The SELTINE cohort of nuclear workers employed by CEA, Orano, and EDF companies was followed-up for mortality from 1968 to 2014. Mortality in the cohort was compared to that in the French general population. Poisson regression methods were used to estimate excess relative rates of mortality per unit of cumulative dose of IR, adjusted for calendar year, age, company, duration of employment, and socioeconomic status. The cohort included 80,348 workers. At the end of the follow-up, the mean attained age was 63 years, and 15,695 deaths were observed. A strong healthy worker effect was observed overall. A significant excess of pleural cancer mortality was observed but not associated with IR dose. Death from solid cancers was positively but non-significantly associated with radiation. Death from leukaemia (excluding chronic lymphocytic leukaemia), dementia, and Alzheimer’s disease were positively and significantly associated with IR dose. Estimated dose–risk relationships were consistent with those from other nuclear worker studies for all solid cancers and leukaemia but remained associated with large uncertainty. The association between IR dose and dementia mortality risk should be interpreted with caution and requires further investigation by other studies.

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Section: Leukaemia Excluding Cllsupporting

confidence: 89%

Section: Mortality Analyses (Comparison With External Reference)mentioning

confidence: 66%

Updated Mortality Analysis of SELTINE, the French Cohort of Nuclear Workers, 1968–2014

Olivier

Samson

Caër-Lorho

et al. 2022

Cancers

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Establishment and activity of the planning and acting network for low dose radiation research in Japan (PLANET): 2016–2023

Yamada,

Imaoka,

Iwasaki

et al. 2024

Journal of Radiation Research

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The Planning and Acting Network for Low Dose Radiation Research in Japan (PLANET) was established in 2017 in response to the need for an all-Japan network of experts. It serves as an academic platform to propose strategies and facilitate collaboration to improve quantitative estimation of health risks from ionizing radiation at low-doses and low-dose-rates. PLANET established Working Group 1 (Dose-Rate Effects in Animal Experiments) to consolidate findings from animal experiments on dose-rate effects in carcinogenesis. Considering international trends in this field as well as the situation in Japan, PLANET updated its priority research areas for Japanese low-dose radiation research in 2023 to include (i) characterization of low-dose and low-dose-rate radiation risk, (ii) factors to be considered for individualization of radiation risk, (iii) biological mechanisms of low-dose and low-dose-rate radiation effects and (iv) integration of epidemiology and biology. In this context, PLANET established Working Group 2 (Dose and Dose-Rate Mapping for Radiation Risk Studies) to identify the range of doses and dose rates at which observable effects on different endpoints have been reported; Working Group 3 (Species- and Organ-Specific Dose-Rate Effects) to consider the relevance of stem cell dynamics in radiation carcinogenesis of different species and organs; and Working Group 4 (Research Mapping for Radiation-Related Carcinogenesis) to sort out relevant studies, including those on non-mutagenic effects, and to identify priority research areas. These PLANET activities will be used to improve the risk assessment and to contribute to the revision of the next main recommendations of the International Commission on Radiological Protection.

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Reanalysis of cancer mortality using reconstructed organ-absorbed dose: J-EPISODE 1991‒2010

Abstract: The revised abstract was written in the revised manuscript pdf and word file in Step 1 and Step 3.

Cited by 2 publications

References 26 publications

Updated Mortality Analysis of SELTINE, the French Cohort of Nuclear Workers, 1968–2014

Updated Mortality Analysis of SELTINE, the French Cohort of Nuclear Workers, 1968–2014

Establishment and activity of the planning and acting network for low dose radiation research in Japan (PLANET): 2016–2023

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